Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy Publisher Pubmed

Razi F¹ ; Meshkani MA² ; Zarrabi F³ ; Sadr M⁴ ; Asgarbeik S⁵ ; Bandarian F⁶ ; Forouzanfar K⁷ ; Amoli MM⁸

Show Affiliations

1. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Biology, School of Basic Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
3. Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Molecular Immunology Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
7. Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
8. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Gene Published:2019

Abstract

Background: Diabetic Nephropathy (DN) is one of the microvascular complications of diabetes and its early diagnosis can improve patient's quality of life. Genetic factors may increase the risk of DN development. This study aimed to evaluate the association of vitamin D receptor (VDR) gene polymorphisms and DN. Method: A total of 313 Iranian participants including 104 diabetic patients with nephropathy (DN), 100 diabetic patients without nephropathy (D) and 109 healthy people (HC) were studied. The frequencies of rs7975232, rs731236 and rs4516035 variants of VDR gene were determined and compared between three groups. Estimated haplotype frequencies between polymorphisms in the cases and controls were also calculated. Results: No significant differences were identified for allele /genotype frequencies in HC, D and DN groups. However haplotype analysis showed that haplotype encompassing CCC alleles for rs7975232, rs731236 and rs4516035 variants, respectively was more frequent in DN subjects compared to HC (p-value = 0.01) and also, haplotype comprising TCC alleles was more frequent in DN group compared to both HC and D groups (p-value = 0.004 and 0.007, respectively). Conclusion: Our study identified that CCC and TCC VDR haplotypes are risk factors for DN in patients with diabetes type 2. © 2018

Related Docs

View other Related Docs

1. Vitamin D Receptor Gene Polymorphisms and Susceptibility to Type 2 Diabetes: Evidence From a Meta-Regression and Meta-Analysis Based on 47 Studies, Journal of Diabetes and Metabolic Disorders (2021)

2. The Vitamin D Receptor Gene Variants, Apai, Taqi, Bsmi, and Foki in Diabetic Foot Ulcer and Their Association With Oxidative Stress, Molecular Biology Reports (2022)

3. Association of Serum Uric Acid With Nephropathy in Iranian Type 2 Diabetic Patients, Journal of Diabetes and Metabolic Disorders (2018)

4. The Role of Errfi1+808T/G Polymorphism in Diabetic Nephropathy, International Journal of Molecular and Cellular Medicine (2019)

5. Association Analysis Between the Vdr Gene Variants and Type 2 Diabetes, Journal of Diabetes and Metabolic Disorders (2023)

6. Agtr1 Rs5186 Variants in Patients With Type 2 Diabetes Mellitus and Nephropathy, Meta Gene (2018)

7. Expression Level of Circulating Cell Free Mir-155 Gene in Serum of Patients With Diabetic Nephropathy, Clinical Laboratory (2019)

8. Achievements and Advances in Diabetes Research Over a Quarter of a Century: A Review of the Available Evidence, Iranian Journal of Diabetes and Metabolism (2021)

Experts (# of related papers)

View all Related Experts

Fatemeh Bandarian (10)

Farideh Razi (8)

Other Related Docs

9. Expression Level of Circulating Mir-93 in Serum of Patients With Diabetic Nephropathy; [Diyabetik Nefropati Hastalarinin Serumlarinda Serbest Mir-93 Ekspresyon Duzeyleri], Turkish Journal of Endocrinology and Metabolism (2018)

10. Vitamin D Receptor Gene Polymorphisms in Iranian Azary Patients With Behcet's Disease, Scandinavian Journal of Rheumatology (2015)

11. Enos Gene Glu298asp Variant Confer Risk in Sudden Sensorineural Hearing Loss, Acta Oto-Laryngologica (2018)

12. An Overview of Diabetes Research Achievements During a Quarter of a Century in Diabetes Research Center, Journal of Diabetes and Metabolic Disorders (2021)

13. Vitamin D Receptor Gene Polymorphisms and the Risk of Metabolic Syndrome (Mets): A Meta-Analysis, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)

14. Vitamin D Receptor Gene Polymorphisms, Metabolic Syndrome, and Type 2 Diabetes in Iranian Subjects: No Association With Observed Snps, International Journal for Vitamin and Nutrition Research (2016)

15. Iran Diabetes Research Roadmap (Idrr) Study: An Overview, Iranian Journal of Public Health (2017)

16. Vdr Gene Polymorphisms Are Associated With the Increased Susceptibility to Covid-19 Among Iranian Population: A Case-Control Study, International Journal of Immunogenetics (2022)

17. Vitamin D Receptor Gene Polymorphisms and the Risk of the Type 1 Diabetes: A Meta-Regression and Updated Meta-Analysis, BMC Endocrine Disorders (2020)

18. Association of Vitamin D Receptor Gene Polymorphism With the Occurrence of Low Bone Density, Osteopenia, and Osteoporosis in Patients With Type 2 Diabetes, Journal of Diabetes and Metabolic Disorders (2021)

19. Stability of Thirty-Four Analytes in Blood Samples of Diabetic Patients, Clinical Laboratory (2020)

20. Genetic Research in Immunogenetics Group of Endocrinology and Metabolism Research Institute, Journal of Diabetes and Metabolic Disorders (2021)

21. Vitamin D Receptor Gene Foki Variant in Diabetic Foot Ulcer and Its Relation With Oxidative Stress, Gene (2017)

22. Mapping Research in Diabetes Complications; a Scoping Review, Journal of Diabetes and Metabolic Disorders (2022)

Style	Citing Format
MLA	Razi F, et al.. "Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy." Gene, vol. 683, no. , 2019, pp. 149-152.
APA	Razi F, Meshkani MA, Zarrabi F, Sadr M, Asgarbeik S, Bandarian F, Forouzanfar K, Amoli MM (2019). Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy. Gene, 683(), 149-152.
Chicago	Razi F, Meshkani MA, Zarrabi F, Sadr M, Asgarbeik S, Bandarian F, Forouzanfar K, Amoli MM. "Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy." Gene 683, no. (2019): 149-152.
Harvard	Razi F et al. (2019) 'Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy', Gene, 683(), pp. 149-152.
Vancouver	Razi F, Meshkani MA, Zarrabi F, Sadr M, Asgarbeik S, Bandarian F, et al.. Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy. Gene. 2019;683():149-152.
BibTex	@article{ author = {Razi F and Meshkani MA and Zarrabi F and Sadr M and Asgarbeik S and Bandarian F and Forouzanfar K and Amoli MM}, title = {Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy}, journal = {Gene}, volume = {683}, number = {}, pages = {149-152}, year = {2019} }
RIS	TY - JOUR AU - Razi F AU - Meshkani MA AU - Zarrabi F AU - Sadr M AU - Asgarbeik S AU - Bandarian F AU - Forouzanfar K AU - Amoli MM TI - Haplotypes in Vitamin D Receptor Gene Encode Risk in Diabetic Nephropathy JO - Gene VL - 683 IS - SP - 149 EP - 152 PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract