Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Immunopathogenesis of Ankylosing Spondylitis: An Updated Review



Daryabor G1 ; Harsini S2, 3 ; Rezaei N2, 3, 4
Authors

Source: Acta Medica Iranica Published:2018

Abstract

Ankylosing spondylitis (AS) is a chronic immune-mediated inflammatory arthritis of unknown etiology, which belongs to a group of conditions known as spondyloarthropathies that comprises psoriatic arthritis, reactive arthritis, and enteropathic arthritis. AS causes pathologic new-bone formation in the axial skeleton, and leads to chronic pain, axial fusion, deformity, disability and skeletal fracture. Several genetic and environmental factors are known to be associated with AS. Notwithstanding the fact that a multitude of genes, such as human leukocyte antigen B27 (HLA-B27), endoplasmic reticulum-associated aminopeptidase 1 (ERAP1), and interleukin-23 receptor (IL-23R) have been previously speculated to be associated with individuals’ susceptibility to AS, no consensus about their precise role in the etiopathogenesis of AS has been reached. In the present study, we summarize the current literature on the immunogenetics of AS and contemporize the research advancement that has been made over the past decade. © 2018 Tehran University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. Role of Innate Immune System in the Pathogenesis of Ankylosing Spondylitis, Biomedicine and Pharmacotherapy (2018)
2. New Insights Toward the Pathogenesis of Ankylosing Spondylitis; Genetic Variations and Epigenetic Modifications, Modern Rheumatology (2017)
3. Hla-B*27 Subtypes and Their Implications in the Pathogenesis of Ankylosing Spondylitis, Gene (2018)
Experts (# of related papers)
View all Related Experts
Mahdi Mahmoudi (10)
Ahmad Reza Jamshidi (8)
Other Related Docs
4. The Roles of Erap1 and Erap2 in Autoimmunity and Cancer Immunity: New Insights and Perspective, Molecular Immunology (2020)
5. Innate Immune-Related Cells and Cytokines in Spondyloarthropathies, Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors (2021)
6. An Overview to Ankylosing Spondylitis and Spondyloarthropathies, Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors (2021)
7. Endoplasmic Reticulum Aminopeptidase 2 Gene Single Nucleotide Polymorphisms in Association With Susceptibility to Ankylosing Spondylitis in an Iranian Population, Immunology Letters (2020)
8. Inhibition of Erap1 Represses Hla-B27 Free Heavy Chains Expression on Polarized Macrophages and Interrupts Nk Cells Activation and Function From Ankylosing Spondylitis, Clinical Immunology (2023)
9. Determination of Il1 R2, Antxr2, Card9, and Snapc4 Single Nucleotide Polymorphisms in Iranian Patients With Ankylosing Spondylitis, Rheumatology International (2016)
10. An Interleukin 12 B Single Nucleotide Polymorphism Increases Il-12P40 Production and Is Associated With Increased Disease Susceptibility in Patients With Relapsing-Remitting Multiple Sclerosis, Neurological Research (2017)
11. Association of the Genetic Variants in the Endoplasmic Reticulum Aminopeptidase 2 Gene With Ankylosing Spondylitis Susceptibility, International Journal of Rheumatic Diseases (2021)
12. Association Between Rs6759298 and Ankylosing Spondylitis in Iranian Population, Avicenna Journal of Medical Biotechnology (2018)
13. Il23r Gene Polymorphism With Juvenile Idiopathic Arthritis and Its Association With Serum Il-17A, International Journal of Rheumatic Diseases (2016)
14. Ankylosing Spondylitis and Mesenchymal Stromal/Stem Cell Therapy: A New Therapeutic Approach, Biomedicine and Pharmacotherapy (2019)
15. Determination of Il-23 Receptor Expression and Gene Polymorphism (Rs1884444) in Iranian Patients With Ankylosing Spondylitis, BMC Rheumatology (2024)
16. Adaptive Immune-Related Cells and Cytokines in Spondyloarthropathies, Ankylosing Spondylitis - Axial Spondyloarthritis: Cellular# Molecular and Environmental Factors (2021)
17. The Association of Interleukin 6 Receptor Gene Variant (Rs4129267) With Susceptibility to Ankylosing Spondylitis and Soluble Il-6 Receptor Level in Iranian Patients, Indian Journal of Rheumatology (2025)
18. The Potent Suppressive Effect of Β-D-Mannuronic Acid (M2000) on Molecular Expression of the Tlr/Nf-Kb Signaling Pathway in Ankylosing Spondylitis Patients, International Immunopharmacology (2017)
19. Increased Inflammatory Responsiveness of Peripheral Blood Mononuclear Cells (Pbmcs) to in Vitro Nod2 Ligand Stimulation in Patients With Ankylosing Spondylitis, Immunopharmacology and Immunotoxicology (2018)
20. Upregulation of Unfolded Protein Response and Er Stress–Related Il-23 Production in M1 Macrophages From Ankylosing Spondylitis Patients, Inflammation (2022)