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Regulation of Stem Cell Fate by Nanomaterial Substrates Publisher Pubmed



Mashinchian O1 ; Turner LA2 ; Dalby MJ2 ; Laurent S3, 4 ; Shokrgozar MA5 ; Bonakdar S5 ; Imani M6 ; Mahmoudi M7, 8, 9
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, PO Box 14177-55469, Tehran, Iran
  2. 2. Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
  3. 3. Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, Mons, B-7000, Belgium
  4. 4. CMMI - Center for Microscopy and Molecular Imaging, Rue Adrienne Bolland, 8, Gosselies, B-6041, Belgium
  5. 5. National Cell Bank, Pasteur Institute of Iran, PO Box 13169-43551, Tehran, Iran
  6. 6. Novel Drug Delivery Systems Department, Iran Polymer and Petrochemical Institute (IPPI), PO Box 14965/115, Tehran, Iran
  7. 7. Department of Nanotechnology and Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, PO Box 14155-6451, Tehran, Iran
  8. 8. Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, 94305-5101, CA, United States
  9. 9. Cardiovascular Institute, Stanford University School of Medicine, Stanford, 94305-5101, CA, United States

Source: Nanomedicine Published:2015


Abstract

Stem cells are increasingly studied because of their potential to underpin a range of novel therapies, including regenerative strategies, cell type-specific therapy and tissue repair, among others. Bionanomaterials can mimic the stem cell environment and modulate stem cell differentiation and proliferation. New advances in these fields are presented in this review. This work highlights the importance of topography and elasticity of the nano-/micro-environment, or niche, for the initiation and induction of stem cell differentiation and proliferation. © 2015 Future Medicine Ltd.
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