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Effect of Green Tea (Camellia Sinensis) Extract on Healing Process of Surgical Wounds in Rat Publisher Pubmed



Asadi SY1 ; Parsaei P2 ; Karimi M3 ; Ezzati S1 ; Zamiri A4 ; Mohammadizadeh F5 ; Rafieiankopaei M6
Authors
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Authors Affiliations
  1. 1. Medical Plants Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  2. 2. Young Researchers Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
  3. 3. Department of Surgery, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: International Journal of Surgery Published:2013


Abstract

Green tea (Camellia sinensis) has anti-oxidant and anti-inflammatory properties and may enhance wound healing process. The present study, therefore, was aimed to examine the effect of green tea ethanolic extract on wound healing process. For this experimental study, 36 healthy male Wistar rats were randomly designated to three groups of A, B, and C which, respectively treated with, Vaseline + 0.6% green tea extract, Vaseline and normal saline for 21 days. Wounds' length and area were measured by caliper every other day and specimens were taken at 3rd, 12th, and 21st day for microscopical examinations. Data were analyzed by SPSS 16 using survival analysis (Breslow test), repeated measured ANOVA, one-way ANOVA and Mann-Whitney. P < 0.05 was considered as statistically significant. The mean healing duration of surgical wounds in groups A and B was 14.66 and 20.66 (P = 0.018), respectively. Decrease in healing duration in the group A was significantly higher within the first two weeks compared with control groups (P = 0.05). Microscopic examinations also indicated a significant difference in wound healing process between groups A and C throughout the whole study duration as well as groups A and B during the 3rd week of the study (P < 0.05).Green tea extract could help wound healing process, probably effective on surgical wounds healing. © 2013 Surgical Associates Ltd.
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