Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Functionalized Graphene Oxide/Fe3o4 Nanocomposite: A Biocompatible and Robust Nanocarrier for Targeted Delivery and Release of Anticancer Agents Publisher Pubmed



Taherikafrani A1 ; Shirzadfar H2 ; Abbasi Kajani A3 ; Kudhair BK4 ; Jasim Mohammed L1 ; Mohammadi S1 ; Lotfi F5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, 81746-73441, Iran
  2. 2. Department of Electrical and Biomedical Engineering, Faculty of Engineering and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran
  3. 3. Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  4. 4. Department of Laboratory Investigations, Faculty of Science, University of Kufa, Najaf, 54001, Iraq
  5. 5. Department of Biomedical Engineering, Sheikhbahaee University, Isfahan, Iran

Source: Journal of Biotechnology Published:2021


Abstract

The development of efficient drug nanocarriers has remained an important challenge in advanced drug delivery in human body. Combination of graphene-based nanomaterials and cyanuric chloride (CC), as a linker, may improve the success of drug delivery. Herein, a simple approach was used for the synthesis of superparamagnetic graphene oxide (SPMGO) nanocomposite through a chemical precipitation method. The nanocomposite was readily functionalized with cyanuric chloride as a linker for loading the drug. The FTIR spectroscopy confirmed the efficient synthesis of nanocarriers. So did the transmission electron microscopy, atomic force microscopy, and thermo-gravimetric analysis, X-ray diffraction and X-ray photoelectron spectroscopy. Subsequently, the synthesized nanocarriers were studied in terms of their potential for biomedical applications. Immobilization of methotrexate (MTX), as a drug for treatment of cancer was taken into action on the SPMGO and SPMGO/CC. The in vitro assays indicated that the drug nanocarrier systems, SPMGO/MTX and SPMGO/CC/MTX, are hemo-compatible and increase the efficiency of MTX against Caov-4, HeLa and MCF-7 cell lines. The MTX nanocarriers represented a considerably high drug loading and controlled drug release. The overall results indicated the great potential of SPMGO/CC/MTX nanocarrier for targeted drug delivery, particularly in MTX chemotherapy. © 2021
Related Docs
View other Related Docs
1. Immobilization of Methotrexate Anticancer Drug Onto the Graphene Surface and Interaction With Calf Thymus Dna and 4T1 Cancer Cells, Bioelectrochemistry (2018)
2. Targeted Delivery of Docetaxel by Use of Transferrin/Poly(Allylamine Hydrochloride)-Functionalized Graphene Oxide Nanocarrier, ACS Applied Materials and Interfaces (2016)
3. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
4. Encapsulation of Drug-Loaded Graphene Oxide-Based Nanocarrier Into Electrospun Pullulan Nanofibers for Potential Local Chemotherapy of Breast Cancer, Macromolecular Chemistry and Physics (2021)
5. Investigation of Combination Effect Between 6 Mv X-Ray Radiation and Polyglycerol Coated Superparamagnetic Iron Oxide Nanoparticles on U87-Mg Cancer Cells, Journal of Biomedical Physics and Engineering (2020)
6. Iron Oxide/Gold Nanoparticles-Decorated Reduced Graphene Oxide Nanohybrid As the Thermo-Radiotherapy Agent, IET Nanobiotechnology (2020)
7. Magnesium-Zinc-Graphene Oxide Nanocomposite Scaffolds for Bone Tissue Engineering, Arabian Journal of Chemistry (2023)
8. Dft Studies of Graphene-Functionalised Derivatives of Capecitabine, Zeitschrift fur Naturforschung - Section A Journal of Physical Sciences (2017)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (12)
Mahboubeh Rostami (4)
Other Related Docs
9. Hyaluronic Acid Targeted Metal Organic Framework Based on Iron (Iii) for Delivery of Platinum Curcumin Cytotoxic Agent to Triple Negative Breast Cancer Cell Line, Applied Organometallic Chemistry (2022)
10. Antibacterial Amorphous Magnesium Phosphate/Graphene Oxide for Accelerating Bone Regeneration, Biomaterials Advances (2022)
11. Mxenes in Photomedicine: Advances and Prospects, Chemical Communications (2022)
12. Genetically Engineered Viral Vectors and Organic-Based Non-Viral Nanocarriers for Drug Delivery Applications, Advanced Healthcare Materials (2022)
13. Penicillin and Oxacillin Loaded on Pegylated-Graphene Oxide to Enhance the Activity of the Antibiotics Against Methicillin-Resistant Staphylococcus Aureus, Pharmaceutics (2022)
14. Construction and Characterization of a Theranostic System Based on Graphene/Manganese Chelate, Biosensors and Bioelectronics (2018)
15. Boron Phenyl Alanine Targeted Chitosan–Pnipaam Core–Shell Thermo-Responsive Nanoparticles: Boosting Drug Delivery to Glioblastoma in Bnct, Drug Development and Industrial Pharmacy (2021)
16. Graphene and Graphene Oxide With Anticancer Applications: Challenges and Future Perspectives, MedComm (2022)
17. 5Fu-Loaded Pcl/Chitosan/Fe3o4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System, Advanced Pharmaceutical Bulletin (2022)
18. Folate-Graphene Chelate Manganese Nanoparticles As a Theranostic System for Colon Cancer Mr Imaging and Drug Delivery: In-Vivo Examinations, Journal of Drug Delivery Science and Technology (2019)
19. Carbon-Based Nanomaterials for Targeted Cancer Nanotherapy: Recent Trends and Future Prospects, Journal of Drug Targeting (2021)
20. Fluorescence Resonance Energy Transfer Monitoring of Ph-Responsive Doxorubicin Release From Carbon Dots/Aptamer Functionalized Magnetic Mesoporous Silica, Nanomedicine (2021)
21. Co-Delivery of Carboplatin and Doxorubicin Using Zif-8 Coated Chitosan-Poly(N-Isopropyl Acrylamide) Nanoparticles Through a Dual Ph/Thermo Responsive Strategy to Breast Cancer Cells, International Journal of Biological Macromolecules (2024)
22. Mn(Ii) & Gd(Iii) Deferrioxamine Complex Contrast Agents & Temozolomide Cancer Prodrug Immobilized on Folic Acid Targeted Graphene/Polyacrylic Acid Nanocarrier: Mri Efficiency, Drug Stability & Interactions With Cancer Cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects (2022)
23. Hierarchical Multifunctional Graphene Oxide Cancer Nanotheranostics Agent for Synchronous Switchable Fluorescence Imaging and Chemical Therapy, Microchimica Acta (2020)
24. Mechanical Behaviour, Hybridisation and Osteoblast Activities of Novel Baghdadite/ Pcl-Graphene Nanocomposite Scaffold: Viability, Cytotoxicity and Calcium Activity, Materials Technology (2022)
25. Mtx-Loaded Dual Thermoresponsive and Ph-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer, Molecular Pharmaceutics (2021)
26. A Drug Delivery System Based on Nanocomposites Constructed From Metal-Organic Frameworks and Mn3o4 Nanoparticles: Preparation and Physicochemical Characterization for Bt-474 and Mcf-7 Cancer Cells, Colloids and Surfaces B: Biointerfaces (2021)
27. Advances in Aptamer-Based Drug Delivery Vehicles for Cancer Therapy, Biomaterials Advances (2022)
28. Dual Thermo- and Ph-Responsive Poly(N-Isopropylacrylamide-Co-(2-Dimethylamino) Ethyl Methacrylate)-G-Peg Nanoparticle System and Its Potential in Controlled Drug Release, Polymer Bulletin (2020)
29. Cytotoxic Effects of Chitosan/Retinoic Acid/Albumin Targeted Nanoparticles Loaded With Doxorubicin on Human Hepatoma Cells, Journal of Isfahan Medical School (2013)
30. Assessment of Ph Responsive Delivery of Methotrexate Based on Phema-St-Peg-Da Nanohydrogels, Macromolecular Research (2021)
31. A Theranostic System Based on Nanocomposites of Manganese Oxide Nanoparticles and a Ph Sensitive Polymer: Preparation, and Physicochemical Characterization, Bioelectrochemistry (2019)
32. Lomustine Loaded Superparamagnetic Iron Oxide Nanoparticles Conjugated With Folic Acid for Treatment of Glioblastoma Multiforma (Gbm), Iranian Journal of Pharmaceutical Research (2020)
33. Investigation on Bioactivity and Cytotoxicity of Mesoporous Nano-Composite Mcm-48/Hydroxyapatite for Ibuprofen Drug Delivery, Ceramics International (2014)
34. Production and Evaluation of Polyblend of Agar and Polyacrylonitrile Nanofibers for in Vitro Release of Methotrexate in Cancer Therapy, Fibers and Polymers (2015)
35. Targeting Graphene Quantum Dots to Epidermal Growth Factor Receptor for Delivery of Cisplatin and Cellular Imaging, Materials Science and Engineering C (2019)
36. Bacterial Cellulose-Based Materials: A Perspective on Cardiovascular Tissue Engineering Applications, ACS Biomaterials Science and Engineering (2023)
37. Fabrication of a Biocompatible & Biodegradable Targeted Theranostic Nanocomposite With Ph-Controlled Drug Release Ability, Journal of Drug Delivery Science and Technology (2022)
38. Fabrication of 3D Porous Polyurethane-Graphene Oxide Scaffolds by a Sequential Two-Step Processing for Non-Load Bearing Bone Defects, Physica Scripta (2024)
39. Biocompatibility of Graphene Oxide Nanosheets Functionalized With Various Amino Acids Towards Mesenchymal Stem Cells, Heliyon (2023)
40. Polymeric Nanoparticles in Cancer Chemotherapy: A Narrative Review, Iranian Journal of Public Health (2022)
41. Enhanced Antitumor Activity of Bovine Lactoferrin Through Immobilization Onto Functionalized Nano Graphene Oxide: An In Vitro/In Vivo Study, Drug Delivery (2020)
42. Co-Delivery of Stat3 Sirna and Methotrexate in Breast Cancer Cells, Artificial Cells, Nanomedicine and Biotechnology (2022)
43. Graphene Oxide-Encapsulated Baghdadite Nanocomposite Improved Physical, Mechanical, and Biological Properties of a Vancomycin-Loaded Pmma Bone Cement, Journal of Biomaterials Science, Polymer Edition (2024)
44. Biodegradable Nanocarriers Based on Chitosan-Modified Mesoporous Silica Nanoparticles for Delivery of Methotrexate for Application in Breast Cancer Treatment, Materials Science and Engineering C (2021)
45. Methotrexate-Conjugated to Polymer Quantum Dot for Cytotoxicity Effect Improved Against Mcf-7 and Hela Cells, Medicinal Chemistry Research (2018)