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Appetite Sensation Improvement by Synbiotic Supplementation in Patients With Metabolic Syndrome: A Randomized Controlled Clinical Trial Publisher

Summary: A study shows synbiotic supplements increase fullness in metabolic syndrome patients but don’t improve glucose or inflammation. #Nutrition #MetabolicHealth

Hosseini F1 ; Pourjam M1 ; Mirzaeian S2 ; Karimifar M3 ; Feizi A3, 4 ; Entezari MH1 ; Sarafbank S5, 6
Authors

Source: Food Science and Nutrition Published:2024


Abstract

The potential link between dysbiosis, features of metabolic syndrome (MetS), inflammation, and sensation impairment has been recently recognized. However, in this context, there are few indications available regarding the effects of co-supplementation with Bacillus indicus, Bacillus coagulans, and fructooligosaccharide (FOS) prebiotics on patients with MetS. Therefore, this study aimed to investigate the effects of synbiotic supplementation on glycemic indices, inflammatory biomarkers, and appetite among adults with MetS. This study is a randomized, double-blind, placebo-controlled clinical trial conducted in the Endocrine and Metabolism Research Center outpatient clinic in Isfahan, Iran. Fifty-eight MetS patients were randomly assigned to receive either synbiotics (n = 29) or placebo (n = 29) supplementation twice per day for 8 weeks. Finally, 55 patients were recruited for analyses (28 in the intervention group and 27 in the placebo group). Random permuted blocks and a computer-generated random number table were used for treatment allocation. No adverse effects were reported during the study. There were no significant differences in glycemic indices and inflammatory markers within- and between groups (all p >.05). However, a significant increase in the sensation of fullness was documented in the synbiotic group. In conclusion, the eight-week treatment did not improve glycemic control and inflammatory markers. Nevertheless, it demonstrated potential efficacy in enhancing participants' appetite sensations, warranting further evaluation in longer intervention periods during future clinical trials. © 2024 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.
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