Pi3k/Akt/Mtor Signaling Pathway Modulation by Circular Rnas in Breast Cancer Progression Publisher Pubmed



Karami Fath M¹ ; Akhavan Masouleh R² ; Afifi N³ ; Loghmani S⁴ ; Tamimi P⁵ ; Fazeli A⁶ ; Mousavian SA⁷ ; Falsafi MM⁸ ; Barati G^{9, 10}
Source: Pathology Research and Practice Published:2023

Abstract

The PI3K/Akt/mTOR signaling pathway is responsible for many cellular behaviors, including survival, growth, and proliferation. A newly identified RNA, circular RNA (circRNA), plays a crucial role in the regulation of gene expression. The upregulation of the PI3K/Akt pathway through dysregulated circRNAs promotes breast tumor initiation, growth, and progression. The dysregulation of PI3K/Akt-regulating circRNAs seems to be directly correlated with breast cancer clinical features, including overall survival, tumor size, cancer stage, and lymph node metastasis. In addition, targeting these circRNAs may be a promising option in cancer-targeted therapy. Understanding the molecular pathogenesis of the circRNA-PI3K/AKT axis may give the insight to develop new therapeutic and diagnostic approaches for breast cancer therapy. Here we reviewed the expression and functions of PI3K/AKT-regulating circRNAs, and their correlation with breast cancer clinical features. In addition, the potential of PI3K/AKT-regulating circRNAs as diagnostic/prognostic biomarkers or therapeutic targets was discussed. © 2022 Elsevier GmbH