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Pi3k/Akt/Mtor Signaling Pathway Modulation by Circular Rnas in Breast Cancer Progression Publisher Pubmed



Karami Fath M1 ; Akhavan Masouleh R2 ; Afifi N3 ; Loghmani S4 ; Tamimi P5 ; Fazeli A6 ; Mousavian SA7 ; Falsafi MM8 ; Barati G9, 10
Authors
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Authors Affiliations
  1. 1. Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  2. 2. School of Medicine, Alborz University of Medical Sciences, Alborz, Iran
  3. 3. School of Medicine, Islamic Azad University, Qeshm Branch, Qeshm, Iran
  4. 4. Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  5. 5. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Education, Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Pharmacy Department, EMU(Eastern Mediterranean University), North Cyprus, Famagusta, Cyprus
  8. 8. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  10. 10. Stem Cell Technology Research Center, Tehran, Iran

Source: Pathology Research and Practice Published:2023


Abstract

The PI3K/Akt/mTOR signaling pathway is responsible for many cellular behaviors, including survival, growth, and proliferation. A newly identified RNA, circular RNA (circRNA), plays a crucial role in the regulation of gene expression. The upregulation of the PI3K/Akt pathway through dysregulated circRNAs promotes breast tumor initiation, growth, and progression. The dysregulation of PI3K/Akt-regulating circRNAs seems to be directly correlated with breast cancer clinical features, including overall survival, tumor size, cancer stage, and lymph node metastasis. In addition, targeting these circRNAs may be a promising option in cancer-targeted therapy. Understanding the molecular pathogenesis of the circRNA-PI3K/AKT axis may give the insight to develop new therapeutic and diagnostic approaches for breast cancer therapy. Here we reviewed the expression and functions of PI3K/AKT-regulating circRNAs, and their correlation with breast cancer clinical features. In addition, the potential of PI3K/AKT-regulating circRNAs as diagnostic/prognostic biomarkers or therapeutic targets was discussed. © 2022 Elsevier GmbH
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