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Effects of Curcumin on Low-Density Lipoprotein Oxidation: From Experimental Studies to Clinical Practice Publisher



Baratzadeh F1, 2 ; Butler AE3 ; Kesharwani P4 ; Moallem SA5, 6 ; Sahebkar A7, 8, 9, 10
Authors
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Authors Affiliations
  1. 1. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Clinical Pharmacy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Research Department, Royal College of Surgeons in Ireland, PO Box 15503, Adliya, Bahrain
  4. 4. Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India
  5. 5. Department of Pharmacology and Toxicology, College of Pharmacy, Al-Zahraa University for Women, Karbala, Iraq
  6. 6. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. School of Medicine, The University of Western Australia, Perth, Australia
  10. 10. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: EXCLI Journal Published:2022


Abstract

Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions. © 2022, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
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