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Effects of Curcumin on Low-Density Lipoprotein Oxidation: From Experimental Studies to Clinical Practice Publisher



Baratzadeh F1, 2 ; Butler AE3 ; Kesharwani P4 ; Moallem SA5, 6 ; Sahebkar A7, 8, 9, 10
Authors

Source: EXCLI Journal Published:2022


Abstract

Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions. © 2022, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
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