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Body Composition and Serum Levels of Matrix Metalloproteinase-9, Adiponectin and Amp-Activated Protein Kinase in Breast Cancer Survivors Publisher



Babaei Z1 ; Parsian H2 ; Korani B3 ; Mostafazadeh A2 ; Moslemi D4
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  3. 3. Department of Clinical Biochemistry, School of Medical Science, Tarbiat Modares University, Tehran, Iran
  4. 4. Department of Radiooncology, Babol University of Medical Sciences, Babol, Iran

Source: Journal of Research in Medical Sciences Published:2022


Abstract

Background: Available data suggest that obesity is related to changes in the several adipocyte-derived proteins levels, which are involved in cancer recurrence. The purpose of this work was to investigate the correlation between obesity with metalloproteinase-9 (MMP-9), adiponectin and adiponectin and AMP-activated protein kinase (AMPK) levels by comparing serum levels of MMP-9, AMPK in normal weight and obese breast cancer survivors. Materials and Methods: In this cross-sectional study, 30 normal weight breast cancer survivors (body mass index [BMI] 18.5-25 kg/m 2) and 30 obese breast cancer survivors (BMI ≥30 kg/m 2) were investigated. Anthropometric parameters and serum levels of MMP-9, adiponectin, and AMPK were compared between the two groups. Results: No differences were detected in the serum levels of MMP-9, adiponectin, and AMPK in obese patients and normal weight patients (P > 0.05). There were no correlations between MMP-9, adiponectin, and AMPK levels with anthropometric measurements in two groups (P > 0.05). Conclusion: We found that there was a lack of correlation between obesity measures and serum levels of MMP-9, adiponectin, and AMPK. In breast cancer survivors, it seems that circulating levels of adiponectin, AMPK, and MMP-9 do not change in obesity state. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
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