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Polysaccharides Derived From Tragacanth As Biocompatible Polymers and Gels Publisher



Fattahi A1, 2, 3 ; Petrini P4 ; Munarin F4 ; Shokoohinia Y5 ; Golozar MA1 ; Varshosaz J3 ; Tanzi MC4
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran
  2. 2. Department of Materials Engineering, Isfahan University of Technology, Isfahan 84146-83111, Iran
  3. 3. Isfahan Pharmaceutical Sciences Research Centre, Isfahan University of Medical Sciences, Isfahan 81745-359, Iran
  4. 4. Laboratorio di Biomateriali, Dipartimento di Chimica, Materiali e Ingegneria Chimica 'G. Natta', Politecnico di Milano, 20133 Milano, Piazza Leonardo da Vinci 32, Italy
  5. 5. Department of Pharmacognosy and Biotechnology, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran

Source: Journal of Applied Polymer Science Published:2013


Abstract

Tragacanth gum (TG) is a natural gum whose biomedical applications are limited because of the low water solubility and the possibility to form only weak water-insoluble gels. An innovative method to produce water-soluble tragacanth (WST) is assessed in this work. WST structural characterization indicates a high-molecular weight polyuronic acid, which can undergo gelling by ionotropic complexation. Biological characterization shows no cytotoxicity on Hela, HepG2, and L929 cell lines. Furthermore, TG-based and WST-based gel beads prepared by ionic crosslinking with ferric and zinc ions are studied. Ferric WST gels exerted better cell adhesion with L929 cells than ferric alginate gels. These characteristics make WST a promising candidate for tissue engineering and drug delivery applications. © 2013 Wiley Periodicals, Inc.
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