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Therapeutic Potential of Mesenchymal Stem Cell-Derived Exosomes As a Cell-Free Therapy Approach for the Treatment of Skin, Bone, and Cartilage Defects Publisher Pubmed



Norouzibarough L1 ; Shirian S2, 3, 4 ; Gorji A4, 5 ; Sadeghi M6, 7, 8, 9
Authors
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Authors Affiliations
  1. 1. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
  3. 3. Shiraz Molecular Pathology Research Center, Dr Daneshbod Pathol Lab, Shiraz, Iran
  4. 4. Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
  5. 5. Epilepsy Research Center, Department of Neurosurgery, Westfalische Wilhelms-Universitat Munster, Munster, Germany
  6. 6. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Molecular Medicine Faculty Advance Medicine of Tabriz University of Medical Sciences, Tabriz, Iran

Source: Connective Tissue Research Published:2022


Abstract

Objective: The aim of this study was to collect the articles concerning mesenchymal stem cell (MSC)-derived exosomes for regeneration of bone, cartilage and skin defects. Method: Scopus, PubMed, EMBASE, and Web of Science were searched for keywords “Exosome, MSC, Skin, Bone and Cartilage defects, Regenerative medicine, and extracellular vesicles. Results: MSC-derived exosomes can emulate the biological activity of MSCs by horizontal transfer of multiple functional molecules including mRNAs, miRNAs, proteins, and lipids to the local microenvironment and recipient cells, and subsequently mediate restoring homeostasis and tissue regeneration through various mechanisms. Compared to MSCs, MSC-derived exosomes reveal many advantages such as non-immunogenicity, easy access, easy preservation, and extreme stability under various conditions. Conclusion: Hence, exosomes could be considered as an alternative strategy for cell-based therapies in regenerative medicine. In this paper, after describing the characteristics of exosomes, we will review the recent literature on the therapeutic potentials of MSC-derived exosomes in skin, bone, and cartilage repair. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
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