Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cross-Linked Poly (Vinyl Alcohol) Hydrogel: Study of Swelling and Drug Release Behaviour



Varshosaz J1 ; Koopaie N1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Sch. of Pharm. and Pharmaceut. Sci., Isfahan University of Med. Sciences, Isfahan, P.O. Box 81745-359, Iran

Source: Iranian Polymer Journal (English Edition) Published:2002

Abstract

Cross-linked poly (vinyl alcohol) (PVA) is a prolonged-release micromatrix, a hydrophilic polymer and a potentially interesting hydrogel, which is useful for drug delivery applications. As a part of drug development procedure the aim of this study was to investigate the effect of structural changes on drug release (theophylline) from this polymeric network. The studied parameters included: cross-linking agent (glutaraldehyde) concentration, PVA content of the films, theophylline percentage and their overall effect on swelling of the hydrogels, drug loading efficiency, diffusion and release characteristics of theophylline from PVA films. Changes in glutaraldehyde percentage (or cross-linking density) affected the swelling of the films. However, increasing PVA percentage caused more swelling. Drug loading efficiency was higher in gels with higher glutaraldehyde, PVA and theophylline percentages. Increasing contents of PVA and theophylline promoted the diffusion coefficient and drug release rate but glutaraldehyde had a reverse effect. The pH did not affect the swelling and diffusion coefficient. Water transport and drug release mechanism predominantly followed a Fickian model. It may be concluded that by changing the PVA structural parameters, a rate-controlled drug release is obtained.
Related Docs
View other Related Docs
1. Characterization of Drug Release and Diffusion Mechanism Through Hydroxyethylmethacrylate/Methacrylic Acid Ph-Sensitive Hydrogel, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2004)
2. Preparation and Evaluation of Theophylline Sustained Release Microcapsules Using Coacervation, Journal of Dispersion Science and Technology (2012)
3. Drug Diffusion Mechanism Through Ph-Sensitive Hydrophobic/Polyelectrolyte Hydrogel Membranes, European Journal of Pharmaceutics and Biopharmaceutics (2001)
4. Novel Multi-Layer Silica Aerogel/Pva Composite for Controlled Drug Delivery, Materials Research Express (2019)
5. Comparing the Drug Loading and Release of Silica Aerogel and Pva Nano Fibers, Journal of Non-Crystalline Solids (2019)
6. Preparation and Characterization of a Sustained Release Buccoadhesive System for Delivery of Terbutaline Sulfate, Research in Pharmaceutical Sciences (2013)
7. Development and Physical Characterization of a Periodontal Bioadhesive Gel of Metronidazole, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2002)
8. Preparation and Characterization of a Hydroxypropyl Methylcellulose Based Wafer for Simultaneous Delivery of Phenytoin and Insulin As Wound Dressing Material, Pharmaceutical Development and Technology (2022)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (22)
Somayeh Taymouri (5)
Other Related Docs
9. Preparation and Pharmaceutical Evaluation of Glibenclamide Slow Release Mucoadhesive Buccal Film, Research in Pharmaceutical Sciences (2014)
10. Application of Taguchi Method to Investigate the Drug Release Behavior of Poly(Acrylamide-Co-Maleic Acid)/Montmorillonite Nanocomposite Hydrogels, Advances in Polymer Technology (2014)
11. Use of Enteric Polymers for Production of Microspheres by Extrusion-Spheronization, Pharmaceutica Acta Helvetiae (1997)
12. Investigation of Drug Release From Biodegradable Polymeric Delivery System by Infrared Spectrometry, International Journal of Polymer Analysis and Characterization (2008)
13. Cytocompatibility and Antibacterial Properties of Coaxial Electrospun Nanofibers Containing Ciprofloxacin and Indomethacin Drugs, Polymers (2022)
14. Coated Urinary Catheter by Peg/Pva/Gentamicin With Drug Delivery Capability Against Hospital Infection, Iranian Polymer Journal (English Edition) (2013)
15. Antibacterial and Ph-Sensitive Methacrylate Poly-L-Arginine/Poly (Β-Amino Ester) Polymer for Soft Tissue Engineering, Journal of Materials Science: Materials in Medicine (2023)
16. Preparation and in Vitro Evaluation of Vancomycin Loaded Montmorillonite-Sodium Alginate Topical Gel for Wound Infection, Brazilian Journal of Pharmaceutical Sciences (2022)
17. Investigating the Performance of Drug Delivery System of Fluconazole Made of Nano–Micro Fibers Coated on Cotton/Polyester Fabric, Journal of Materials Science: Materials in Medicine (2017)
18. Use of Natural Gums and Cellulose Derivatives in Production of Sustained Release Metoprolol Tablets, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2006)
19. The Effect of Formulation Variables on the Characteristics of Insulin-Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres Prepared by a Single Phase Oil in Oil Solvent Evaporation Method, Colloids and Surfaces B: Biointerfaces (2009)
20. Investigation of Drug Release and 1H-Nmr Analysis of the in Situ Forming Systems Based on Poly(Lactide-Co-Glycolide), Polymers for Advanced Technologies (2009)
21. Fabrication and Evaluation of Hesperidin Loaded Polyacrylonitrile/Polyethylene Oxide Nanofibers for Wound Dressing Application, Journal of Biomaterials Science, Polymer Edition (2021)
22. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
23. Preparation and Physicochemical Evaluation of Nystatine Mucoadhesive Buccal Film, Journal of Reports in Pharmaceutical Sciences (2013)
24. Multifunctional Electrospun Polyvinyl Alcohol/Gellan Gum/Polycaprolactone Nanofibrous Membrane Containing Pentoxifylline to Accelerate Wound Healing, Polymer Bulletin (2023)
25. Use of Hydrophilic Natural Gums in Formulation of Sustained-Release Matrix Tablets of Tramadol Hydrochloride, AAPS PharmSciTech (2006)
26. Surface Modification of Poly (Ethylene Terephthalate) Fabric by Soy Protein Isolate Hydrogel for Wound Dressing Application, International Journal of Polymeric Materials and Polymeric Biomaterials (2019)
27. Three-Dimensional (3D) Printed Tablets Using Ethyl Cellulose and Hydroxypropyl Cellulose to Achieve Zero Order Sustained Release Profile, Cellulose (2020)
28. Development and Characterization of Buccoadhesive Nifedipine Tablets, European Journal of Pharmaceutics and Biopharmaceutics (2002)
29. Core-Shell Nanofibers of Poly (Ε-Caprolactone) and Polyvinylpyrrolidone for Drug Delivery System, Materials Research Express (2019)
30. Production and Evaluation of Polyblend of Agar and Polyacrylonitrile Nanofibers for in Vitro Release of Methotrexate in Cancer Therapy, Fibers and Polymers (2015)
31. Preparation and in Vitro Evaluation of Sustained-Release Matrix Tablets of Flutamide Using Synthetic and Naturally Occurring Polymers, Iranian Journal of Pharmaceutical Research (2008)
32. Injectable Gellan Gum/Lignocellulose Nanofibrils Hydrogels Enriched With Melatonin Loaded Forsterite Nanoparticles for Cartilage Tissue Engineering: Fabrication, Characterization and Cell Culture Studies, Materials Science and Engineering C (2020)
33. Influence of Β - Cyclodextrin Complexation on Lovastatin Release From Osmotic Pump Tablets (Opt), Daru (2007)
34. A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications, Nanochemistry Research (2024)
35. A Bifunctional Electrospun Nanocomposite Wound Dressing Containing Surfactin and Curcumin: In Vitro and in Vivo Studies, Materials Science and Engineering C (2021)
36. Fabrication and Characterization of a Novel Wound Dressing With Clindamycin Loaded Pva Nanoparticles for Acne Treatment, Fibers and Polymers (2022)
37. The Effect of Structural Changes on Swelling Kinetics of Polybasic/Hydrophobic Ph-Sensitive Hydrogels, Drug Development and Industrial Pharmacy (1998)
38. Optimization of Self-Assembling Properties of Fatty Acids Grafted to Methoxy Poly(Ethylene Glycol) As Nanocarriers for Etoposide, Acta Pharmaceutica (2012)
39. Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System, Drug Development and Industrial Pharmacy (2007)
40. Preparation, Characterization and Optimization of Glipizide Controlled Release Nanoparticles, Research in Pharmaceutical Sciences (2014)
41. Preparation, Physicochemical, and Retinal Anti-Angiogenic Evaluation of Poloxamer Hydrogel Containing Dexamethasone/Avastin-Loaded Chitosan-N-Acetyl-L-Cysteine Nanoparticles, International Journal of Biological Macromolecules (2022)
42. Preparation and Characterization of Metoprolol Controlled-Release Solid Dispersions, Drug Delivery (2006)
43. Mechanical Properties and Drug Release Behavior of Pcl/Zein Coated 45S5 Bioactive Glass Scaffolds for Bone Tissue Engineering Application, Data in Brief (2015)
44. Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design, Journal of Nanomaterials (2012)
45. Hydrogels and Biohydrogels: Investigation of Origin of Production, Production Methods, and Application, Polymer Bulletin (2023)
46. Thermosensitive Hydrogel Containing Sertaconazole Loaded Nanostructured Lipid Carriers for Potential Treatment of Fungal Keratitis, Pharmaceutical Development and Technology (2019)
47. Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles, Gels (2022)
48. Double-Walled Microspheres Loaded With Meglumine Antimoniate: Preparation, Characterization and in Vitro Release Study, Drug Development and Industrial Pharmacy (2014)