Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Molecular Mechanisms of Drug Resistance in Ovarian Cancer Publisher Pubmed



Norouzibarough L1 ; Sarookhani MR2 ; Sharifi M3 ; Moghbelinejad S4 ; Jangjoo S5 ; Salehi R3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Molecular Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  2. 2. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  3. 3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biochemistry and Genetic, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  5. 5. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Journal of Cellular Physiology Published:2018


Abstract

Ovarian cancer is the most lethal malignancy among the gynecological cancers, with a 5-year survival rate, mainly due to being diagnosed at advanced stages, recurrence and resistance to the current chemotherapeutic agents. Drug resistance is a complex phenomenon and the number of known involved genes and cross-talks between signaling pathways in this process is growing rapidly. Thus, discovering and understanding the underlying molecular mechanisms involved in chemo-resistance are crucial for management of treatment and identifying novel and effective drug targets as well as drug discovery to improve therapeutic outcomes. In this review, the major and recently identified molecular mechanisms of drug resistance in ovarian cancer from relevant literature have been investigated. In the final section of the paper, new approaches for studying detailed mechanisms of chemo-resistance have been briefly discussed. © 2017 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. Sirna and Epigenetic Aberrations in Ovarian Cancer, Journal of Cancer Research and Therapeutics (2016)
2. Crispr/Cas9, a New Approach to Successful Knockdown of Abcb1/P-Glycoprotein and Reversal of Chemosensitivity in Human Epithelial Ovarian Cancer Cell Line, Iranian Journal of Basic Medical Sciences (2018)
3. Microrna: A Novel Target of Curcumin in Cancer Therapy, Journal of Cellular Physiology (2018)
4. Crispr Technology: A Versatile Tool to Model, Screen, and Reverse Drug Resistance in Cancer, European Journal of Cell Biology (2023)
5. Mechanisms of Apoptosis-Related Non-Coding Rnas in Ovarian Cancer: A Narrative Review, Apoptosis (2025)
6. Non-Coding Rnas in Leukemia Drug Resistance: New Perspectives on Molecular Mechanisms and Signaling Pathways, Annals of Hematology (2024)
7. Effects of Abcg2 C421a and Abcg2 G34a Genetic Polymorphisms on Clinical Outcome and Response to Imatinib Mesylate, in Iranian Chronic Myeloid Leukemia Patients, Egyptian Journal of Medical Human Genetics (2023)
8. Epi-Mirnas: Regulators of the Histone Modification Machinery in Human Cancer, Journal of Oncology (2022)
Experts (# of related papers)
View all Related Experts
Rasoul Salehi (3)
Mansour Homayoun (2)
Other Related Docs
9. The Emerging Role of Circular Rnas in Cisplatin Resistance in Ovarian Cancer: From Molecular Mechanism to Future Potential, Non-coding RNA Research (2024)
10. Early Apoptosis Induction in Mcf-7 Breast Cancer Cells by Bacterial Exopolysaccharide-Coated Magnetic Iron Oxide Nanoparticles, International Journal of Biological Macromolecules (2025)
11. In Vitro Evaluation of the Pogostone Effects on the Expression of Pten and Dact1 Tumor Suppressor Genes, Cell Cycle, and Apoptosis in Ovarian Cancer Cell Line, Research in Pharmaceutical Sciences (2022)
12. Meta-Analysis of Gene Signatures and Key Pathways Indicates Suppression of Jnk Pathway As a Regulator of Chemo-Resistance in Aml, Scientific Reports (2021)
13. Curcumin in Advancing Treatment for Gynecological Cancers With Developed Drug- and Radiotherapy-Associated Resistance, Reviews of Physiology, Biochemistry and Pharmacology (2019)
14. Involvement of Aberrant Regulation of Epigenetic Mechanisms in the Pathogenesis of Parkinson's Disease and Epigenetic-Based Therapies, Journal of Cellular Physiology (2019)
15. Glioblastoma and Chemoresistance to Alkylating Agents: Involvement of Apoptosis, Autophagy, and Unfolded Protein Response, Pharmacology and Therapeutics (2018)
16. Mitochondrial and Caspase Pathways Are Involved in the Induction of Apoptosis by Nardosinen in Mcf-7 Breast Cancer Cell Line, Research in Pharmaceutical Sciences (2018)
17. Exosomal Micrornas and Long Noncoding Rnas: Novel Mediators of Drug Resistance in Lung Cancer, Journal of Cellular Physiology (2022)
18. Plasma Level of Mir-21 and Mir-451 in Primary and Recurrent Breast Cancer Patients, Breast Cancer: Targets and Therapy (2019)
19. Long Noncoding Rna-Mirna-Mrna Axes Multiple Roles in Osteosarcoma, Gene Reports (2021)
20. Silibinin Exerts Anti-Cancer Activity on Human Ovarian Cancer Cells by Increasing Apoptosis and Inhibiting Epithelial-Mesenchymal Transition (Emt), Gene (2022)
21. Novel Insights Into the Role of Circular Rnas in Parkinson Disease: An Emerging Renaissance in the Management of Neurodegenerative Diseases, Journal of Neuroscience Research (2022)
22. Glucosamine Reverses Drug Resistance in Mrp2 Overexpressing Ovarian Cancer Cells, European Journal of Pharmacology (2020)
23. Anti-Proliferative and Anti-Apoptotic Effects of Grape Seed Extract on Chemo-Resistant Ovcar-3 Ovarian Cancer Cells, Research in Pharmaceutical Sciences (2020)
24. Methotrexate-Conjugated to Polymer Quantum Dot for Cytotoxicity Effect Improved Against Mcf-7 and Hela Cells, Medicinal Chemistry Research (2018)
25. Epi-Drugs and Epi-Mirs: Moving Beyond Current Cancer Therapies, Current Cancer Drug Targets (2016)