Natural Remedies That Offset Alpha-Linolenic Acid (Ala) Deficiency in Cardiovascular Hallmarks and Complications



Hajibabaie F^{1, 2} ; Abedpoor N¹ ; Kaviani E³ Show Affiliations
Source: Properties and Uses of Linolenic Acid Published:2023

Abstract

The growing number of evidence has shown that dietary lipids influence the development of atherosclerosis, cardiac arrest, abnormal heart rhythms, lipid profile, and cardiovascular risk. Coronary heart disease, cerebrovascular disease, rheumatic heart disease, and various disturbances of the blood arteries system and heart functions are all included in the category of cardiovascular diseases (CVDs). An estimated 17.9 million people worldwide lose their lives each year to cardiovascular diseases (CVDs). Inherited and sporadic forms of cardiovascular disease both have their origins in a combination of genetic predisposition and exposure to adverse environmental variables such as sedentary behavior, smoking, and a diet rich in fatty acids. One of the most important aspects of arterial thrombus is atherosclerosis, which occurs as a result of plaque buildup and rupture of artery walls in patients with dyslipidemia. By maintaining low-density lipoproteins (LDL) under the endothelium, cholesterol homeostasis was disrupted, activating inflammatory cascades and causing the migration of monocytes to areas of inflammation. All of these things cause cardiac cells to produce more reactive oxygen species (ROS). Some molecular physiologists have hypothesized that chronic inflammation, apoptosis, and oxidative stress play critical roles in contributing to cardiovascular pathogenesis. Due to the obvious evidence showing the beneficial properties of plant-based nutrition and long-chain n-3 fatty acids, there is a great interest to discover more about the effects of the plant-based n-3 fatty acid alphalinolenic acid (ALA) on cardiovascular disease, and metabolic syndrome. This chapter reviews the existing literature on ALA and gives a brief overview of the many cardiovascular attractive features of ALA. © 2023 Nova Science Publishers, Inc. All rights reserved.