Tehran University of Medical Sciences

Science Communicator Platform

Faculty Members have conducted research related to the Immunomodulatory Effects of Glycyrrhizin and Glucomannan on Cytokine Gene Expression in Human Pbmcs: Implications for Vaccine Adjuvant Development
Mohammad Hossein Yazdi
Mohammad Hossein Yazdi

Associate Professor of Pharmaceutical Biotechnology

Biotechnology Research Center

Tehran University of Medical Sciences

All Documents
1. Biogenic Selenium Nanoparticles Potentiate Anti-Mesothelin Car-T Cell Therapy in a Syngeneic Tnbc Model, Transplantation and Cellular Therapy (2026)
2. Enhanced Immunogenicity of Staphylococcus Aureus Isde Vaccine With Senps and Bcg Adjuvants in Mice, AMB Express (2026)
3. Glycyrrhizic Acid Increased Fmd Vaccine Potency In a Mineral-Based Adjuvant, But Not In An Oil-Based Adjuvant, Acta Veterinaria Hungarica (2026)
4. Immunomodulatory Effects of Glycyrrhizin and Glucomannan on Cytokine Gene Expression in Human Pbmcs: Implications for Vaccine Adjuvant Development, DARU, Journal of Pharmaceutical Sciences (2026)
5. In Silico Design of a Multi-Epitope Vaccine Against Nsclc Targeting T-Cell Exhaustion and Metastasis: Insights From Rna-Seq and Molecular Dynamics Simulation Analysis, Network Modeling Analysis in Health Informatics and Bioinformatics (2026)
6. Synergistic Immunoenhancement of Recombinant Pbp2a Vaccine Candidate by Biogenic Selenium Nanoparticles and Mf59 Against Methicillin-Resistant Staphylococcus Aureus, Current Microbiology (2026)
7. A Novel Broad-Spectrum Bacteriophage Cocktail Against Methicillin-Resistant Staphylococcus Aureus: Isolation, Characterization, and Therapeutic Potential in a Mastitis Mouse Model, PLoS ONE (2025)
8. Cost-Reduction Strategy to Culture Patient Derived Bladder Tumor Organoids, Scientific Reports (2025)
9. Evaluation of the Performance of Bcg With Synthetic Nano Selenium As a Booster in the Formulation of a Vaccine Candidate Against Staphylococcus Aureus Based on Isde in a Mouse Model; [ارزیابی عملکرد ب ث ژ به همراه نانو سلنیوم سنتتیک به عنوان تقویتکننده در فرمولاسیون واکسن کاندید علیه استافیلوکوکوس اورئوس بر پایهی Isde در مدل موشی], Journal of Isfahan Medical School (2025)
10. Immunogenic Potential of Biogenic Vs. Synthetic Selenium Nanoparticles in Vaccine Candidate Against Methicillin-Resistant Staphylococcus Aureus, Vaccine: X (2025)
11. Interferon Signaling and Sting Pathway in Head and Neck Cancers: Unlocking Immune Secrets and Therapeutic Frontiers, Cancer Cell International (2025)
12. Molecular Reflection of the Mind: Exosomes in Major Depressive Disorder, Brain Research Bulletin (2025)
13. Photo-Mediated Biological Preparation of Silver Nanoparticles Paste in an Organic Solvent System: Formulation and Antimicrobial Studies, Applied Physics A: Materials Science and Processing (2025)
14. Probiotic Intervention Alters Immune Gene Expression and Tumor Characteristics in Experimental Breast Cancer, Molecular Biology Reports (2025)
15. Ascorbic Acid and Α-Tocopherol in the Inactivated Sars-Cov-2 Vaccine Formulation: Induction of the Th1 Pattern in Aged Mice, Viral Immunology (2024)
16. Candidiasis in Breast Cancer: Tumor Progression or Not?, Iranian Journal of Basic Medical Sciences (2024)
17. Generation of Murine Chimeric Antigen Receptor-Modified T Cells for in Vivo Studies in Syngeneic Tumor Models, Current Protocols (2024)
18. Monophosphoryl Lipid a As a Co-Adjuvant in Methicillin-Resistant Staphylococcus Aureus Vaccine Development: Improvement of Immune Responses in a Mouse Model of Infection, Immunologic Research (2024)
19. Selenium Nanoparticles: Characteristics, Production, and Applications, (2024)
20. The Strategic Role of Biotics in Dental Caries Prevention: A Scoping Review, Food Science and Nutrition (2024)
21. Antimicrobial Effects of Postbiotic Mediators Derived From Lactobacillus Rhamnosus Gg and Lactobacillus Reuteri on Streptococcus Mutans, Frontiers in Bioscience - Landmark (2023)
22. Cancer Vaccines for Triple-Negative Breast Cancer: A Systematic Review, Vaccines (2023)
23. Glucomannan As a Polysaccharide Adjuvant Improved Immune Responses Against Staphylococcus Aureus: Potency and Efficacy Studies, Microbial Pathogenesis (2023)
24. Glucomannan Enhanced the Macrophage Activity in Exposure to Methicillin-Resistant Staphylococcus Aureus (Mrsa): In-Vitro Study, Iranian Journal of Microbiology (2023)
25. Investigating the Effect of Monophosphoryl Lipid a As a Co-Adjuvant on Humoral Immune Response Against Staphylococcus Aureus Infection in a Mouse Model; [بررسی اثر مونوفسفوریل لیپید a به عنوان یک ادجوانت کمکی بر روی پاسخهای ایمنی همورال علیه عفونت ستافیلوکوکوس اورئوس در مدل موشی], Journal of Isfahan Medical School (2023)
26. Looking Into the Toxicity Potential and Clinical Benefits of Tyrosine Kinase Inhibitors (Tkis), Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 (2023)
27. Selenium Nanoparticle-Enriched Lactobacillus Plantarum Causes More Anti-Carcinogenic Effect on Human Colon Cancer Cells Compared to Non-Enriched Ones, BioNanoScience (2023)
28. Synthetic Selenium Nanoparticles As Co-Adjuvant Improved Immune Responses Against Methicillin-Resistant Staphylococcus Aureus, World Journal of Microbiology and Biotechnology (2023)
29. The Cytotoxicity of Tellurium Nanoparticles on Different Cell Lines and Their in Vivo Anticancer Effects in an Animal Model, Middle East Journal of Cancer (2023)
30. Glucomannan As a Dietary Supplement for Treatment of Breast Cancer in a Mouse Model, Vaccines (2022)
31. Green Synthesis of Selenium Nanoparticles in the Presence of Mycobacterium Bovis Cell Lysate: A Novel Fabrication Approachand Its Immune-Modulatory Effects, Nano Biomedicine and Engineering (2022)
32. Photo-Mediated Preparation of Silver Nanoparticles Dry Concentrate in an Organic Solvent System, Using Culture Supernatant of Klebsiella Pneumonia: A Preliminary Study, Journal of Sciences# Islamic Republic of Iran (2022)
33. Potentiation of the Therapeutic Effect of Intravesical Bcg Through Synthetic and Biogenic Selenium Nanoparticles in a Nitrosamine-Induced Bladder Cancer Mouse Model, Advances in Cancer Biology - Metastasis (2022)
34. Selenium Nanoparticles As a Co-Adjuvant With Autolysin Recombinant Protein in the Development of a Vaccine Candidate Against Methicillin-Resistant Staphylococcus Aureus, Journal of Isfahan Medical School (2022)
35. A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies, Carbohydrate Polymers (2021)
36. Comparison of Cytokine Expression in Human Pbmcs Stimulated With Normal and Heat-Shocked Lactobacillus Plantarum Cell Lysate, Probiotics and Antimicrobial Proteins (2021)
37. Effect of Prevalent Polychlorinated Biphenyls (Pcbs) Food Contaminant on the Mcf7, Lncap and Mda-Mb-231 Cell Lines Viability and Pon1 Gene Expression Level: Proposed Model of Binding, DARU# Journal of Pharmaceutical Sciences (2021)
38. Fabrication of Calcium Sulfate Coated Selenium Nanoparticles and Corresponding In-Vitro Cytotoxicity Effects Against 4T1 Breast Cancer Cell Line, Avicenna Journal of Medical Biotechnology (2021)
39. Formulation of a Recombinant Hiv-1 Polytope Candidate Vaccine With Naloxone/Alum Mixture: Induction of Multi-Cytokine Responses With a Higher Regulatory Mechanism, APMIS (2021)
40. Molecular Cloning and Immunogenicity Evaluation of Isde Protein of Methicillin Resistant Staphylococcus Aureus As Vaccine Candidates, Microbial Pathogenesis (2021)
41. Nanobodies in Human Infections: Prevention, Detection, and Treatment, Immunological Investigations (2020)
42. Potential Vaccines for Treating Crohn's Disease, Iranian Biomedical Journal (2020)
43. Research Paper: The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cellline:Aninvitrocomparison, International Journal of Medical Toxicology and Forensic Medicine (2020)
44. An Overview on Probiotics As an Alternative Strategy for Prevention and Treatment of Human Diseases, Iranian Journal of Pharmaceutical Research (2019)
45. Effects of Exercise Training and Supplementation With Selenium Nanoparticle on T-Helper 1 and 2 and Cytokine Levels in Tumor Tissue of Mice Bearing the 4 T1 Mammary Carcinoma, Nutrition (2019)
46. Molecular Cloning and Immunogenicity Evaluation of Ppic, Gele, and Vs87_01105 Proteins of Enterococcus Faecalis As Vaccine Candidates, Iranian Biomedical Journal (2019)
47. Recombinant Staphylococcal Antigen-F (R-Scaf), a Novel Vaccine Candidate Against Methicillin Resistant Staphylococcus Aureus Infection: Potency and Efficacy Studies, Microbial Pathogenesis (2019)
48. Biosynthesis of Senps by Mycobacterium Bovis and Their Enhancing Effect on the Immune Response Against Hbs Antigens: An in Vivo Study, IET Nanobiotechnology (2018)
49. Cbpm and Cbpg of Streptococcus Pneumoniae Elicit a High Protection in Mice Challenged With a Serotype 19F Pneumococcus, Iranian Journal of Allergy# Asthma and Immunology (2018)
50. Characterization of Folic Acid Surface-Coated Selenium Nanoparticles and Corresponding in Vitro and in Vivo Effects Against Breast Cancer, Archives of Medical Research (2018)
51. Co-Utilization of a Tlr5 Agonist and Nano-Formulation of Hiv-1 Vaccine Candidate Leads to Increased Vaccine Immunogenicity and Decreased Immunogenic Dose: A Preliminary Study, Immunology Letters (2017)
52. Combined Effect of Aerobic Interval Training and Selenium Nanoparticles on Expression of Il-15 and Il-10/Tnf-Α Ratio in Skeletal Muscle of 4T1 Breast Cancer Mice With Cachexia, Cytokine (2017)
53. Comparative Safety and Efficacy of Tyrosine Kinase Inhibitors (Tkis) in the Treatment Setting of Different Types of Leukemia, and Different Types of Adenocarcinoma, Biomedicine and Pharmacotherapy (2017)
54. Immune Responses of Mice Immunized With Hbsag Formulated in Naloxone/Alum Mixture: Comparison to Fendrix Vaccine, Hepatitis Monthly (2017)
55. Oral Administration of Synthetic Selenium Nanoparticles Induced Robust Th1 Cytokine Pattern After Hbs Antigen Vaccination in Mouse Model, Journal of Infection and Public Health (2017)
56. Recombinant Pbp2a As a Vaccine Candidate Against Methicillin-Resistant Staphylococcus Aureus: Immunogenicity and Protectivity, Microbial Pathogenesis (2017)
57. The Determination of Biomass/Selenium Ratio and the Impact of Glucose and Piperitone Upon Selenium Ion Reduction Using Bacillus Sp. Msh-1 Whole Cells, Nano Biomedicine and Engineering (2017)
58. Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology, Nano Biomedicine and Engineering (2016)
59. Passive Immunity by Recombinant Anti-Methicillin-Resistant Staphylococcus Aureus Scaf Antibody in Mouse Model, Journal of Mazandaran University of Medical Sciences (2016)
60. A Comprehensive Review of Clinical Trials on Egfr Inhibitors Such As Cetuximab and Panitumumab As Monotherapy and in Combination for Treatment of Metastatic Colorectal Cancer, Avicenna Journal of Medical Biotechnology (2015)
61. Adjuvant Effect of Biogenic Selenium Nanoparticles Improves the Immune Responses and Survival of Mice Receiving 4T1 Cell Antigens As Vaccine in Breast Cancer Murine Model, Journal of Nanoscience and Nanotechnology (2015)
62. Dose-Response Relationship Study of Selenium Nanoparticles As an Immunostimulatory Agent in Cancer-Bearing Mice, Archives of Medical Research (2015)
63. Ranibizumab and Aflibercept for the Treatment of Wet Age-Related Macular Degeneration, Expert Opinion on Biological Therapy (2015)
64. Th1 Immune Response Induction by Biogenic Selenium Nanoparticles in Mice With Breast Cancer: Preliminary Vaccine Model, Iranian Journal of Biotechnology (2015)