Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Faculty Members have conducted research related to the A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells As a Novel Carrier for Suicide Gene Delivery
Mahmoud Reza Hadjighassem
Mahmoud Reza Hadjighassem

Associate Professor of Neuroscience

Department Neuroscience and Addiction Studies

School of Advanced Technologies in Medicine

Brain and Spinal Cord Injury Research Center

Tehran University of Medical Sciences

All Documents
1. Protective Effects of Heat-Killed Lactobacilli Against Plasma-Induced Neurotoxicity in Multiple Sclerosis, Probiotics and Antimicrobial Proteins (2025)
2. A Novel Approach for Mucosal and Bulbar Olfactory Ensheathing Cells Isolation Based on the Non-Adherent Subculturetechnique, Basic and Clinical Neuroscience (2024)
3. Combination Chemotherapy Via Poloxamer 188 Surface-Modified Plga Nanoparticles That Traverse the Blood–Brain–Barrier in a Glioblastoma Model, Scientific Reports (2024)
4. Evaluation of Secretome Biomarkers in Glioblastoma Cancer Stem Cells: A Bioinformatics Analysis, Cancer Reports (2024)
5. Advances in Management of Spinal Cord Injury Using Stem Cell-Derived Extracellular Vesicles: A Review Study, Basic and Clinical Neuroscience (2023)
6. Effect of Folate-Targeted Erlotinib Loaded Human Serum Albumin Nanoparticles on Tumor Size and Survival Rate in a Rat Model of Glioblastoma, Life Sciences (2023)
7. Effect of Multifactorial Therapeutic Approach on Axonal Regeneration and Cell Viability in an In-Vitro Model of Spinal-Derived Neural Injury, Cell and Tissue Banking (2023)
8. Erratum: Correction To: Effect of Multifactorial Therapeutic Approach on Axonal Regeneration and Cell Viability in an In-Vitro Model of Spinal-Derived Neural Injury (Cell and Tissue Banking (2023) 24 2 (471-484)), Cell and tissue banking (2023)
9. Evaluation of the Effect of Mesenchymal Stem Cells Injection in the Nucleus Accumbens on the Morphine Reinstatement Behavior in a Conditioned Place Preference Model in Wistar Rat: Expression Changes of Nmda Receptor Subunits and Nt-3, Behavioural Brain Research (2023)
10. Exosomes Released From U87 Glioma Cells Treated With Curcumin And/Or Temozolomide Produce Apoptosis in Naive U87 Cells, Pathology Research and Practice (2023)
11. Fluoxetine Enhances the Antitumor Effect of Olfactory Ensheathing Cell-Thymidine Kinase/Ganciclovir Gene Therapy in Human Glioblastoma Multiforme Cells Through Upregulation of Connexin43 Levels, Drug Development Research (2023)
12. Long-Term Bumetanide Administration Altered Behavioral Pattern in Mosaic Down’S Syndrome: A Case Report, Applied Neuropsychology: Child (2023)
13. The Effect of Collagen and Fibrin Hydrogels Encapsulated With Adipose Tissue Mesenchymal Stem Cell-Derived Exosomes for Treatment of Spinal Cord Injury in a Rat Model, Iranian Journal of Biotechnology (2023)
14. Ac-Sdkp Peptide Improves Functional Recovery Following Spinal Cord Injury in a Preclinical Model, Neuropeptides (2022)
15. Antiproliferative Activity of New Derivatives of Pyrazino[1,2-A]Benzimidazole: Integrated Cell-Based Assay and Computational Studies With Divalent Magnesium, Iron, and Copper Ions, Journal of Biochemical and Molecular Toxicology (2022)
16. Decoding Selective Attention and Cognitive Control Processing Through Stroop Interference Effect: An Event-Related Electroencephalography-Derived Study, Iranian Journal of Psychiatry and Behavioral Sciences (2022)
17. Detection of Glioblastoma Multiforme Using Quantitative Molecular Magnetic Resonance Imaging Based on 5-Aminolevulinic Acid: In Vitro and in Vivo Studies, Magnetic Resonance Materials in Physics# Biology and Medicine (2022)
18. Effect of Tramadol on Apoptosis and Synaptogenesis in Hippocampal Neurons: The Possible Role of Μ-Opioid Receptor, Drug Development Research (2022)
19. Investigation of Anti-Cancer Effects of New Pyrazino[1,2-A]Benzimidazole Derivatives on Human Glioblastoma Cells Through 2D in Vitro Model and 3D-Printed Microfluidic Device, Life Sciences (2022)
20. Long-Term Administration of Bumetanide Improve Functional Recovery After Spinal Cord Injury in Rats, Frontiers in Pharmacology (2022)
21. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)
22. Nkcc1 to Kcc2 Mrna Ratio in Schizophrenia and Its Psychopathology: A Case–Control Study, Journal of Molecular Neuroscience (2022)
23. Novel Therapeutic Approach to Slow Down the Inflammatory Cascade in Acute/Subacute Spinal Cord Injury: Early Immune Therapy With Lipopolysaccharide Enhanced Neuroprotective Effect of Combinational Therapy of Granulocyte Colony-Stimulating Factor and Bone-Marrow Mesenchymal Stem Cell in Spinal Cord Injury, Frontiers in Cellular Neuroscience (2022)
24. Preclinical Gene Therapy in Glioblastoma Multiforme: Using Olfactory Ensheathing Cells Containing a Suicide Gene, Life Sciences (2022)
25. Β2-Adrenergic Receptor Agonist Enhances the Bystander Effect of Hsv-Tk/Gcv Gene Therapy in Glioblastoma Multiforme Via Upregulation of Connexin 43 Expression, Molecular Therapy Oncolytics (2022)
26. Analgesic Effect of Bumetanide on Neuropathic Pain in Patients With Spinal Cord Injury, Basic and Clinical Neuroscience (2021)
27. Assessment of Cytotoxic Effects of New Derivatives of Pyrazino[1,2-A] Benzimidazole on Isolated Human Glioblastoma Cells and Mitochondria, Life Sciences (2021)
28. Effect of Paclitaxel/Etoposide Co-Loaded Polymeric Nanoparticles on Tumor Size and Survival Rate in a Rat Model of Glioblastoma, International Journal of Pharmaceutics (2021)
29. Repair of Injured Spinal Cord Using Platelet-Rich Plasma- and Endometrial Stem Cells-Loaded Chitosan Scaffolds, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
30. Widespread Disruptions of White Matter in Familial Multiple Sclerosis: Dti and Noddi Study, Frontiers in Neurology (2021)
31. Conductive Biomaterials As Nerve Conduits: Recent Advances and Future Challenges, Applied Materials Today (2020)
32. Effects of Multiple Injections on the Efficacy and Cytotoxicity of Folate-Targeted Magnetite Nanoparticles As Theranostic Agents for Mri Detection and Magnetic Hyperthermia Therapy of Tumor Cells, Scientific Reports (2020)
33. Fibrin Hydrogel As a Scaffold for Differentiation of Induced Pluripotent Stem Cells Into Oligodendrocytes, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2020)
34. Potential Role of Exosome in Post-Stroke Reorganization And/Or Neurodegeneration, EXCLI Journal (2020)
35. Preliminary Study of Analgesic Effect of Bumetanide on Neuropathic Pain in Patients With Spinal Cord Injury, Journal of Clinical Neuroscience (2020)
36. Β2-Adrenergic Receptor Stimulation Upregulates Cx43 Expression on Glioblastoma Multiforme and Olfactory Ensheathing Cells, Journal of Molecular Neuroscience (2020)
37. A Preliminary Study Evaluating the Safety and Efficacy of Bumetanide, an Nkcc1 Inhibitor, in Patients With Drug-Resistant Epilepsy, CNS Drugs (2019)
38. Bioinspired Immobilization of Carbon Nanotubes on Scaffolds for Nerve Regeneration, Bioinspired# Biomimetic and Nanobiomaterials (2019)
39. Brain Microstructural Abnormalities Correlate With Kcc2 Downregulation in Refractory Epilepsy, NeuroReport (2019)
40. Correction To: A Preliminary Study Evaluating the Safety and Efficacy of Bumetanide, an Nkcc1 Inhibitor, in Patients With Drug-Resistant Epilepsy (Cns Drugs, (2019), 33, 3, (283-291), 10.1007/S40263-019-00607-5), CNS Drugs (2019)
41. Longitudinal Effects of Bumetanide on Neuro-Cognitive Functioning in Drug-Resistant Epilepsy, Frontiers in Neurology (2019)
42. Acute Transplantation of Human Olfactory Mucosa-Derived Olfactory Ensheathing Cells Fails to Improve Locomotor Recovery in Rats, Acta Medica Iranica (2018)
43. Acute Transplantation of Human Olfactory Mucosa-Derived Olfactory Ensheathing Cells Fails to Improve Locomotor Recovery in Rats, Acta Medica Iranica (2018)
44. Blockade of P75 Neurotrophin Receptor Reverses Irritability and Anxiety-Related Behaviors in a Rat Model of Status Epilepticus, Iranian Biomedical Journal (2018)
45. Tumoricidal Effect of Human Olfactory Ensheathing Cell Mediated Suicide Gene Therapy in Human Glioblastoma Cells, Molecular Biology Reports (2018)
46. In Vitro Differentiation of Neural Stem Cells Derived From Human Olfactory Bulb Into Dopaminergic-Like Neurons, European Journal of Neuroscience (2017)
47. Neuregulin-1 Gene and Schizophrenia, and Its Negative Symptoms in an Iranian Population, Iranian Journal of Psychiatry and Behavioral Sciences (2017)
48. Rolipram Potentiates Bevacizumab-Induced Cell Death in Human Glioblastoma Stem-Like Cells, Life Sciences (2017)
49. The Role of Protein Kinase B Signaling Pathway in Anti-Cancer Effect of Rolipram on Glioblastoma Multiforme: An in Vitro Study, Basic and Clinical Neuroscience (2017)
50. A New Approach in Gene Therapy of Glioblastoma Multiforme: Human Olfactory Ensheathing Cells As a Novel Carrier for Suicide Gene Delivery, Molecular Neurobiology (2016)
51. Association Between Neuregulin-1 Gene Variant (Rs2439272) and Schizophrenia and Its Negative Symptoms in an Iranian Population, Iranian Journal of Psychiatry (2016)
52. Brain Derived Neurotrophic Factor Modification of Epileptiform Burst Discharges in a Temporal Lobe Epilepsy Model, Basic and Clinical Neuroscience (2016)
53. Efficacy of Human Adipose Tissue-Derived Stem Cells on Neonatal Bilirubin Encephalopathy in Rats, Neurotoxicity Research (2016)
54. Traumatic Brain Injury Accelerates Kindling Epileptogenesis in Rats, Neurological Research (2016)
55. Trpv1 Receptors Augment Basal Synaptic Transmission in Ca1 and Ca3 Pyramidal Neurons in Epilepsy, Neuroscience (2016)
56. Camp-Epac Pathway Stimulation Modulate Connexin-43 and Microrna-21 Expression in Glioma Cells, Basic and Clinical Neuroscience (2015)
57. Effects of Trpv1 on the Hippocampal Synaptic Plasticity in the Epileptic Rat Brain, Synapse (2015)
58. Gender and Age Related Changes in Number of Dopaminergic Neurons in Adult Human Olfactory Bulb, Journal of Chemical Neuroanatomy (2015)
59. Lipopolysaccharide Preconditioning Prevents Acceleration of Kindling Epileptogenesis Induced by Traumatic Brain Injury, Journal of Neuroimmunology (2015)
60. Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans, Nutrition Journal (2015)
61. The Effect of Intrathecal Delivery of Bone Marrow Stromal Cells on Hippocampal Neurons in Rat Model of Alzheimer’S Disease, Iranian Journal of Basic Medical Sciences (2015)
62. Bumetanide Reduces Seizure Frequency in Patients With Temporal Lobe Epilepsy, Epilepsia (2013)