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Pectin-Cellulose Hydrogel, Silk Fibroin and Magnesium Hydroxide Nanoparticles Hybrid Nanocomposites for Biomedical Applications Publisher Pubmed



Eivazzadehkeihan R1 ; Ahmadpour F1 ; Aliabadi HAM2, 3 ; Radinekiyan F1 ; Maleki A1 ; Madanchi H4, 5 ; Mahdavi M6 ; Shalan AE7, 8 ; Lancerosmendez S7, 9
Authors
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Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Advanced Chemistry Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  4. 4. Department of Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  5. 5. Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  6. 6. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. BCMaterials, Basque Center for Materials, Applications and Nanostructures, Martina Casiano, UPV/EHU Science Park, Barrio Sarriena s/n, Leioa, 48940, Spain
  8. 8. Central Metallurgical Research and Development Institute (CMRDI), P. O. Box 87, Helwan, 11421, Cairo, Egypt
  9. 9. IKERBASQUE, Basque Foundation for Science, Bilbao, 48009, Spain

Source: International Journal of Biological Macromolecules Published:2021


Abstract

Natural polymers are at the center of materials development for biomedical and biotechnological applications based on their biocompatibility, low-toxicity and biodegradability. In this study, a novel nanobiocomposite based on cross-linked pectin-cellulose hydrogel, silk fibroin, and Mg(OH)2 nanoparticles was designed and synthesized. After extensive physical-chemical characterization, the biological response of pectin-cellulose/silk fibroin/Mg(OH)2 nanobiocomposite scaffolds was evaluated by cell viability, red blood cells hemolytic and anti-biofilm assays. After 3 days and 7 days, the cell viability of this nanobiocomposite scaffold was 65.5% and 60.5% respectively. The hemolytic effect was below 20%. Furthermore, the presence of silk fibroin and Mg(OH)2 nanoparticles allowed to enhance the anti-biofilm activity, inhibiting the P. aeruginosa biofilm formation. © 2021 Elsevier B.V.
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