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A Facile Way to Synthesize a Photocrosslinkable Methacrylated Chitosan Hydrogel for Biomedical Applications Publisher



Samani S1 ; Bonakdar S2 ; Farzin A1 ; Hadjati J1 ; Azami M1
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. National Cell Bank, Pasteur Institute of Iran, Tehran, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2021


Abstract

In this study, we introduced a novel and modified method to synthesize photocrosslinkable chitosan hydrogel. Three methacrylated samples under two concentrations of methacrylic anhydride and using EDC/NHS as a crosslinker were prepared. Methacrylated chitosan obtained under controlled conditions and using EDC/NHS had significant coupling efficiency and capacity of gel formation compared to other samples. Diluted culture media provided a favorable solubility condition for methacrylated chitosan and could be tolerated by cells during gelation time. The hydrogels included interconnected pores ranging 100–300 µm and swelling ratios of 40–400%. The results opened the new aspects for developing novel biomaterials in cell-based therapies. © 2020 Taylor & Francis Group, LLC.
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