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The Single and Synergistic Effects of Montmorillonite and Curcumin-Loaded Chitosan Microparticles Incorporated Onto Poly(Lactic Acid) Electrospun Film on Wound-Healing Publisher



Naserinosar M1 ; Salehi M2 ; Farzamfar S3 ; Azami M1
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahrud, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Bioactive and Compatible Polymers Published:2018


Abstract

In this study, the single and synergistic effects of montmorillonite and curcumin-loaded chitosan microparticles incorporated onto the polylactic acid films were investigated on full-thickness excisional wounds of rats. The polylactic acid microfibrillated film was electrospun from a 10% (w/v) polylactic acid in chloroform solution. The curcumin-loaded chitosan microparticles were prepared via ionic gelation technique with high drug loading and encapsulation efficiency. The alkaline-treated polylactic acid films were assembled with positively charged chitosan as the first layer and the negatively charged montmorillonite (NC dressing), curcumin-loaded chitosan microparticles (CCM dressing), and their mixture (1:1 (v/v); NC/CCM dressing) as the second layer via layer-by-layer self-assembly technique. The montmorillonite incorporation increased the hydrophobicity and water vapor transmission rate of the CCM dressing but decreased its water-uptake capacity. The films showed good cytocompatibility to L929 fibroblastic cell line, and the in vivo wound-closure percentage result showed that CCM > NC > NC/CCM > sterile gauze. The overall result indicated that the montmorillonite and curcumin-loaded chitosan microparticles had no considerable positive synergistic effects onwound-healing. © 2017, © The Author(s) 2017.
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