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The Single and Synergistic Effects of Montmorillonite and Curcumin-Loaded Chitosan Microparticles Incorporated Onto Poly(Lactic Acid) Electrospun Film on Wound-Healing Publisher



Naserinosar M1 ; Salehi M2 ; Farzamfar S3 ; Azami M1
Authors

Source: Journal of Bioactive and Compatible Polymers Published:2018


Abstract

In this study, the single and synergistic effects of montmorillonite and curcumin-loaded chitosan microparticles incorporated onto the polylactic acid films were investigated on full-thickness excisional wounds of rats. The polylactic acid microfibrillated film was electrospun from a 10% (w/v) polylactic acid in chloroform solution. The curcumin-loaded chitosan microparticles were prepared via ionic gelation technique with high drug loading and encapsulation efficiency. The alkaline-treated polylactic acid films were assembled with positively charged chitosan as the first layer and the negatively charged montmorillonite (NC dressing), curcumin-loaded chitosan microparticles (CCM dressing), and their mixture (1:1 (v/v); NC/CCM dressing) as the second layer via layer-by-layer self-assembly technique. The montmorillonite incorporation increased the hydrophobicity and water vapor transmission rate of the CCM dressing but decreased its water-uptake capacity. The films showed good cytocompatibility to L929 fibroblastic cell line, and the in vivo wound-closure percentage result showed that CCM > NC > NC/CCM > sterile gauze. The overall result indicated that the montmorillonite and curcumin-loaded chitosan microparticles had no considerable positive synergistic effects onwound-healing. © 2017, © The Author(s) 2017.
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