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Enhanced Osteogenic Differentiation of Mesenchymal Stem Cells on Metal–Organic Framework Based on Copper, Zinc, and Imidazole Coated Poly-L-Lactic Acid Nanofiber Scaffolds Publisher Pubmed



Telgerd MD1 ; Sadeghinia M2 ; Birhanu G3, 4 ; Daryasari MP1 ; Zandikarimi A5 ; Sadeghinia A6 ; Akbarijavar H7 ; Karami MH5 ; Seyedjafari E5
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
  3. 3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences International Campus (TUMS-IC), Tehran, Iran
  4. 4. School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
  5. 5. Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
  6. 6. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Biomedical Materials Research - Part A Published:2019


Abstract

The presence of inorganic bioactive minerals with polymers can accelerate and promote several processes including: bone cell joining, proliferation, differentiation, and expression of osteogenic proteins. In this study, zinc (Zn), copper (Cu), and imidazole metal–organic framework (MOF) nanoparticles were synthesized and coated over poly-l-lactic acid (PLLA) nanofibrous scaffolds for bone tissue engineering application. The surface and bioactive features of the scaffolds were characterized. The osteogenic potential of the scaffolds on human adipose tissue-derived mesenchymal stem cells (MSCs) was evaluated. Zn–Cu imidazole MOF coated PLLA scaffolds (PLLA@MOF) showed a comparable rate of MSC proliferation with the pure PLLA scaffolds and tissue culture plate (TCP). However, the PLLA@MOF potential of osteogenic differentiation was significantly greater than either pristine PLLA scaffolds or TCP. Hence, coating Zn–Cu imidazole MOF has a significant effect on the osteogenesis of MSC. Therefore, PLLA@MOF is novel scaffolds with bioactive components which are crucial for osteoconductivity and also able to provoke the osteogenesis and angiogenesis. © 2019 Wiley Periodicals, Inc.
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