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Cutaneous Adverse Reactions Following Covid-19 Vaccinations: A Systematic Review and Meta-Analysis Publisher Pubmed



Shafieei M1 ; Jamali M2 ; Akbari Z1 ; Sarvipour N1 ; Ahmadzade M3 ; Ahramiyanpour N4
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Gene Therapy Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Departments of Plastic Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Dermatology, Afzalipour Hospital, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Source: Journal of Cosmetic Dermatology Published:2022


Abstract

Background: COVID-19 vaccines are currently the most effective interventions in controlling and preventing severe disease progression. Dermatologic reactions to COVID-19 vaccinations may be rare among clinical trial participants. However, since global mass vaccination became a reality, these adverse effects may become more widespread, and different skin reactions would arise. Objective: To systematically review the cutaneous adverse reactions in cases subject to vaccines for COVID-19. Methods: We searched the PubMed, SCOPUS, Web of Science, and Embase databases, identifying the relevant records and including the eligible observational ones. After assessing the methodological quality of the included studies, we qualitatively and quantitatively synthesized the data regarding the cutaneous side effects experienced by those in the studies' population. Results: Overall, 36 studies were included in our systematic review, with the majority being cross-sectional. We found that pain, erythema, and swelling were the most common local side effects, while different types of rashes, urticaria, and angioedema were the most non-local. Few cases also reported experiencing flare-ups of their underlying diseases or developing newly-onset diseases of various etiologies. Our meta-analyses also found that while viral vector-based vaccines are, though insignificantly, safer in injection site complaints, individuals who received mRNA vaccines developed significantly fewer non-local cutaneous adverse events. Discussion: Cutaneous reactions to the COVID-19 vaccines are similar to common cutaneous drug eruptions and COVID-19 cutaneous manifestations. However, we believe that further high-quality research is needed to assess better how and why cutaneous reactions occur in different vaccines. © 2022 Wiley Periodicals LLC.
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