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Microrna and Gynecological Cancers: Focus on Mir-195 Publisher Pubmed



Davoodvandi A1, 2 ; Rafiyan M2 ; Mansournia MA3 ; Rajabpoor Nikoo N4 ; Saati M5 ; Samimi M6 ; Asemi Z2
Authors
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Authors Affiliations
  1. 1. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Gynecology and Obstetrics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Nursing, Semnan Branch, Islamic Azad University, Semnan, Iran
  6. 6. Department of Gynecology and Obstetrics, Kashan University of Medical Sciences, Kashan, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Different cancer types have been shown to have down-regulated expression levels of miR-195 as an anti-tumor agent. MiR-195 family members can inhibit cancer cell proliferation, angiogenesis, epithelial-mesenchymal transition and metastases, immunosuppression, glycolysis, drug resistance, and cancer stem cell development by targeting the 3′-UTR of the mRNA of different pro-tumor genes. MiR-195 identified as a tumor suppressor miR in a variety of cancers, most notably gynecological malignancies such as cervical, endometrial, and ovarian carcinoma. As a result, restoring miR-195 expression should be regarded as a potential therapy for either prevention or treatment of gynecological cancers. This review will present the most recent data about miR-195-mediated anti-tumor effects in gynecological malignancies, emphasizing its downstream signaling pathways and target genes, as well as prospective treatment techniques. © 2023 Elsevier GmbH
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