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Protective Effects of Curcumin Against Medulloblastoma: A Review Publisher



Elahi M1 ; Arefnezhad R2, 3 ; Sattarshamsabadi M3 ; Heidari N4 ; Goleij P5, 6, 7 ; Jafariardakan Z8 ; Soltani ZE1 ; Amirian R7, 9, 10 ; Rezaeitazangi F11
Authors
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Authors Affiliations
  1. 1. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Coenzyme R Research Institute, Tehran, Iran
  3. 3. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Department of Genetics, Sana Institute of Higher Education, Sari, Iran
  6. 6. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  7. 7. USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran
  8. 8. Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  9. 9. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  10. 10. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  11. 11. Department of Anatomy, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

Source: Natural Product Communications Published:2024


Abstract

Medulloblastoma (MB) is the most common childhood tumor with a poor prognosis. Primary approaches for treating MB comprise surgical resection along with radiotherapy and chemotherapy. However, these methods have not created a promising outlook for subjects with this neuroepithelial tumor due to their low efficiency. On the other hand, these therapeutic strategies are associated with many side effects. So, there is an unmet need to find an alternative way to overcome MB. Currently, there is a significant focus on natural compound-based therapies, particularly curcumin obtained from Curcuma longa, for ameliorating different disorders like cancer. Extensive research has also been conducted to provide evidence supporting the beneficial effects of curcumin in the treatment of MB. This polyphenolic compound can exert its suppressive effects on the proliferation and growth of MB cells by affecting several molecular pathways and agents, such as suppressing Wnt/β-catenin, NF-κB, and SHH signaling pathways, triggering apoptosis-related genetic effectors (eg, Bax, Bcl-2, PARP, caspase-3, and caspase-9), potentiating tubulin acetylation, and decreasing HDAC4 function. Hence, in this literature review, we aimed to debate documents pertaining to MB therapy with curcumin and other formulations in vitro and in vivo with a mechanistic insight. © The Author(s) 2024.
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