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Fabrication of Electroactive Nanocomposite Based on Carbon Nanofibers/Magnesium Oxide Nanoparticles for Bone Tissue Engineering Publisher



Derakhshankhah H1 ; Nekounam H2 ; Izadi Z1, 3 ; Allahyari Z4 ; Samari M5 ; Feizi M6 ; Samadian H1
Authors
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Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States
  5. 5. Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, 67144�14971, Iran
  6. 6. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

Bone tissue engineering requires sophisticated and well-tailored scaffolds mimicking the structure and properties of native bone. Carbon nanofibers (CNFs) exhibit fascinating physicochemical and biological properties due to their nanometric diameter and carbonaceous structure. The main objective of the current study is to fabricate a promising scaffold based on CNFs composited with magnesium oxide nanoparticles (MgO-NPs). The MgO-NPs were synthesized using the chemical reaction and added into polyacrylonitrile polymer (the precursor of CNFs), electrospun, and converted to CNFs through the heat treatment steps. The fabricated CNFs/MgO-NPs nanocomposites were characterized using SEM imaging, EDX, XRD, FTIR, and WCA. The results indicated that the synthesized nanoparticles were uniform, pure, and high-crystallinity form. As it is evident, the NPs are uniform and monodisperse with an average size of 97 ± 16 nm. The results showed that incorporating MgO-NPs improved the surface properties of the pristine CNFs. Also, the diameter of carbon nanofibers decreased by adding nanoparticles and the nanoparticles have a uniform distribution in the nanofibers. The WCA values for CNFs/MgO-NPs 5, 10, and 15% were 100 ± 10, 56 ± 3, 46 ± 6, and 38 ± 5°, respectively. The results of in vitro tests also showed that the nanofibers with 15% NPs had the lowest amount of hemolysis and, in other words, the most hemocompatibility. By introducing MgO-NPs, cell viability was increased. The results indicated that combining the nanofibrous structure of CNFs with the particulate morphology of MgO-NPs resulted in a nanocomposite with properties beneficial for bone tissue engineering. © 2023 Elsevier B.V.
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