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Palladium-Catalyzed Regioselective Heck-Suzuki-Miyaura Cascade Cyclization for the Synthesis of Trisubstituted Arylideneisoquinolinones Publisher



Asgari MS1 ; Mirzazadeh R2 ; Larijani B3 ; Rashidi Ranjbar P1 ; Rahimi R4 ; Mahdavi M3
Authors
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Authors Affiliations
  1. 1. School of Chemistry, University College of Chemistry, University of Tehran Tehran, PO Box 14155-6455, Iran
  2. 2. Biochemistry Department, Pasteur Institute of Iran, Pasteur Avenue, Tehran, 1316943551, Iran
  3. 3. Department of Medicinal Chemistry, Facaulty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medicinal Sciences, Tehran, Iran
  4. 4. Department of Chemistry, Iran University of Science and Technology, Narmak, Tehran, 16846-13114, Iran

Source: Synlett Published:2019


Abstract

An Ugi four-component reaction was used to construct propargylamide starting materials for a subsequent domino Heck-Suzuki-Miyaura cross-coupling reaction to give derivatives of 4-benzylidene-1-oxo-3,4-dihydro-1 H -isoquinoline. © Georg Thieme Verlag Stuttgart - New York.