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Emerging Role of Lncrnas in the Etiology of Recurrent Implantation Failure Publisher Pubmed



Fathi M1 ; Ghahghaeinezamabadi A2 ; Ghafourifard S1
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Authors Affiliations
  1. 1. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2024


Abstract

Recurrent implantation failure (RIF) is a complex clinical entity with several molecular pathways contributing to its pathogenesis. Long non-coding RNAs (lncRNAs) have recently been found to affect the normal implantation, thus aberrant expression of these transcripts is involved in RIF. Altered expression of HOXA11-AS, NONHSAT193031.1, NONHSAT053761.2, NONHSAT083203.2, LUCAT1, PART1, TUNAR, LINC02190, lncSAMD11–1:1 and H19 has been reported in this condition. Moreover, polymorphisms within some lncRNAs have been shown to be associated with miscarriage/RIF. The current review article summarizes the recent data about the role of lncRNAs in RIF. This information would pave the way for identification of the molecular events in this context. © 2023
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2. Lncrnas in the Regulation of Endometrial Receptivity for Embryo Implantation, Jornal Brasileiro de Reproducao Assistida (2024)
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