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Burden of Skin and Subcutaneous Diseases in Iran and Neighboring Countries: Results From the Global Burden of Disease Study 2015 Pubmed



Karimkhani C1 ; Dellavalle RP1, 2, 3 ; Karimi SM4 ; Rahimimovaghar V5 ; Pourmalek F6, 7 ; Kiadaliri AA8 ; Ali Sahraian M9 ; Roshandel G10 ; Fereshtehnejad SM11 ; Qorbani M12 ; Radfar A13 ; Farvid MS14 ; Asayesh H15 ; Sepanlou SG16 Show All Authors
Authors
  1. Karimkhani C1
  2. Dellavalle RP1, 2, 3
  3. Karimi SM4
  4. Rahimimovaghar V5
  5. Pourmalek F6, 7
  6. Kiadaliri AA8
  7. Ali Sahraian M9
  8. Roshandel G10
  9. Fereshtehnejad SM11
  10. Qorbani M12
  11. Radfar A13
  12. Farvid MS14
  13. Asayesh H15
  14. Sepanlou SG16
  15. Djalalinia S17, 18
  16. Kasaeian A19
  17. Khubchandani J20
  18. Malekzadeh R16
  19. Moradilakeh M21
  20. Krohn KJ22
  21. Vos T22
  22. Naghavi M22
Show Affiliations
Authors Affiliations
  1. 1. Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
  2. 2. Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States
  3. 3. Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health System, Denver, CO, United States
  4. 4. Interdisciplinary Arts and Sciences, University of Washington, Tacoma, WA, United States
  5. 5. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Urology, University of British Columbia, Vancouver, BC, Canada
  7. 7. School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada
  8. 8. Clinical Epidemiology Unit, Orthopaedics, Department of Clinical Sciences-Lund, Lund University, Lund, Sweden
  9. 9. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  11. 11. Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
  12. 12. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  13. 13. College of Graduate Health Studies, A.T. Still University, Mesa, AZ, United States
  14. 14. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  15. 15. Department of Medical Emergencies, Qom University of Medical Sciecnes, Qom, Iran
  16. 16. Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  17. 17. Development of Research and Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
  18. 18. Non-communicable Diseases Research Center, EMRI, Tehran University of Medical Sciences, Tehran, Iran
  19. 19. Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  20. 20. Department of Nutrition and Health Science, Ball State University, Muncie, IN, United States
  21. 21. Community Medicine Specialist, Preventive Medicine and Public Health Research Center, Department of Community Medicine, Iran University of Medical Sciences, Tehran, Iran
  22. 22. Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United States

Source: Archives of Iranian Medicine Published:2017


Abstract

BACKGROUND: Iran and its neighboring countries represent four world regions with unique cultures and geography. Skin diseases span a wide diversity of etiologies including infectious, inflammatory, autoimmune, vascular, neurogenic, and oncologic. The Global Burden of Disease Study (GBD) 2015 measures the burden from skin diseases in 195 countries. METHODS: Epidemiologic data were collected from literature review, survey data, and hospital inpatient/outpatient claims data. These raw data entered modeling using a Bayesian meta-regression tool, DisMod MR-2.1, which yielded prevalence estimates by age/sex/location/year. Prevalence estimates were combined with disability weights to yield years lived with disability (YLDs). YLDs are combined with years of life lost (YLLs), from mortality estimates, to yield disability-adjusted life years (DALYs). DALYs were obtained for 16 skin conditions and both sexes in Iran and 15 surrounding countries. The sociodemographic index (SDI) for each country was also correlated with skin disease DALY rate using the Pearson coefficient (r) with two-tailed p-value. RESULTS: There was no significant correlation between individual skin diseases and SDI. Acne and dermatitis caused the greatest burden and BCC the lowest burden of skin diseases in Iran and the other 15 countries. SCC and BCC were responsible for the largest discrepancy by sex, with higher burden in males compared to females. CONCLUSION: Skin diseases, particularly dermatitis and acne, cause considerable burden in Iran and surrounding regions. Objective and transparent epidemiologic data such as GBD has the potential to inform and impact many facets of healthcare, research prioritization, public policy, and international partnerships. © 2017, Academy of Medical Sciences of I.R. Iran. All rights reserved.
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