Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Spatial Profiling Technologies and Applications for Brain Cancers Publisher Pubmed



Kalitade Croft P1 ; Sadeghi Rad H2 ; Gasper H3, 4 ; Obyrne K5, 6, 7 ; Lakhani SR1, 8 ; Kulasinghe A5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Oncology, Royal Brisbane and Women’s Hospital, Herston, Australia
  4. 4. School of Medicine, University of Queensland, Herston, QLD, Australia
  5. 5. The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University ofTechnology, Woolloongabba, QLD, Australia
  6. 6. Translational Research Institute, Brisbane, QLD, Australia
  7. 7. Princess Alexandra Hospital, Brisbane, QLD, Australia
  8. 8. Pathology Queensland, The Royal Brisbane and Women’s Hospital Herston, QLD, Australia

Source: Expert Review of Molecular Diagnostics Published:2021


Abstract

Introduction: Malignant primary and secondary brain tumors pose a major health challenge, and the incidence of these tumors is rising. The brain tumor microenvironment (TME) is highly complex and thought to impact treatment resistance and failure. To enable a greater understanding of the milieu of cells in the brain TME, advances in imaging and sequential profiling of proteins/mRNA have given rise to the field of spatial transcriptomics. These technologies provide a greater depth of understanding of the tissue architecture, cellular and spatial profiles, including cellular activation status, which may provide insights into effective therapies for brain cancers. Areas Covered: In this review, we provide an overview of spatial profiling technologies at the forefront in the field and describe the applications for brain cancer. Expert opinion: Brain tumors are often resistant to treatment, and display both an immunosuppressive and heterogeneous tumor microenvironment. Next-generation imaging and multi-omics technologies are providing a tool for intricately characterizing their tissue biology. This information will aid in the design of effective therapies and begin to provide an understanding of therapy resistance. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. The Evolving Landscape of Predictive Biomarkers in Immuno-Oncology With a Focus on Spatial Technologies, Clinical and Translational Immunology (2020)
2. Tumor Immunology, Clinical Immunology (2022)
3. Imaging Signatures of Glioblastoma Molecular Characteristics: A Radiogenomics Review, Journal of Magnetic Resonance Imaging (2020)
4. The Safety and Efficacy of Bevacizumab in Treatment of Recurrent Low-Grade Glioma: A Systematic Review and Meta-Analysis, European Journal of Clinical Pharmacology (2024)
5. Immune Checkpoint Inhibitors in Cancer Therapy, Current Oncology (2022)
6. Lung Cancer-Associated Brain Metastasis: Molecular Mechanisms and Therapeutic Options, Cellular Oncology (2017)
7. The Epidemiology of Brain and Spinal Cord Tumors, Advances in Experimental Medicine and Biology (2023)
8. The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy, Molecular Biology Reports (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (8)
Reza Shirkoohi (2)
Other Related Docs
9. Car-Engineered Nk Cells Versus Car T Cells in Treatment of Glioblastoma; Strength and Flaws, Journal of Neuro-Oncology (2025)
10. Development of a Hydrogel-Based Three-Dimensional (3D) Glioblastoma Cell Lines Culture As a Model System for Cd73 Inhibitor Response Study, BioMedical Engineering Online (2024)
11. Macrophage’S Role in Solid Tumors: Two Edges of a Sword, Cancer Cell International (2023)
12. A Viral Attack on Brain Tumors: The Potential of Oncolytic Virus Therapy, Journal of NeuroVirology (2024)
13. Distinct Tumor-Tam Interactions in Idh-Stratified Glioma Microenvironments Unveiled by Single-Cell and Spatial Transcriptomics, Acta Neuropathologica Communications (2024)
14. The Economic Burden of Malignant Brain Tumors, Advances in Experimental Medicine and Biology (2023)
15. Metastatic Breast Cancer at a Glance: Scenarios of Bc Brain- and Bc Bone-Metastasis by Illustrations, Cancer Genetics and Psychotherapy (2017)
16. Expansion of the Quality of Care Index on Breast Cancer and Its Risk Factors Using the Global Burden of Disease Study 2019, Cancer Medicine (2023)
17. A Study of Platelet-Derived Growth Factor a and Its Ligand Among Patients With Glioblastoma and Astrocytoma in Imam Khomeini Hospital Complex, Tehran, Journal of Advances in Medical and Biomedical Research (2023)
18. Genetic Prognostic Factors in Adult Diffuse Gliomas: A 10-Year Experience at a Single Institution, Cancers (2024)
19. Epidemiology and Socioeconomic Correlates of Brain and Central Nervous System Cancers in Asia in 2020 and Their Projection to 2040, Scientific Reports (2024)
20. Immune Checkpoint Inhibitor (Ici) Therapy in Central Nervous System Cancers: State-Of-The-Art and Future Outlook, International Immunopharmacology (2025)
21. Burden of Breast Cancer and Attributable Risk Factors in the North Africa and Middle East Region, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019, Frontiers in Oncology (2023)
22. Exploration of Involved Key Genes and Signaling Diversity in Brain Tumors, Cellular and Molecular Neurobiology (2018)
23. Immunotherapeutic Targets in Non-Small Cell Lung Cancer, Immunology (2023)
24. Descriptive Epidemiology of Brain and Central Nervous System Tumours: Results From Iran National Cancer Registry, 2010-2014, Journal of Cancer Epidemiology (2020)
25. A Narrative Review of Tumor-Associated Macrophages in Lung Cancer: Regulation of Macrophage Polarization and Therapeutic Implications, Translational Lung Cancer Research (2021)
26. Autophagy in Cancers Including Brain Tumors: Role of Micrornas, Cell Communication and Signaling (2020)