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Biomedical Applications of Bombyx Mori Silk in Skin Regeneration and Cutaneous Wound Healing Publisher Pubmed



Khosropanah MH1, 2 ; Ghofrani A1, 3 ; Vaghasloo MA2, 5 ; Zahir M1, 4 ; Bahrami A1 ; Azimzadeh A1 ; Hassannejad Z1 ; Majidi Zolbin M1
Authors
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Authors Affiliations
  1. 1. Pediatric Urology and Regenerative Medicine Research Center, Gene Cell & Tissue Research Institute, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran Polytechnic, Tehran, Iran
  4. 4. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Persian Medicine Network (PMN), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Biomedical Materials (Bristol) Published:2025


Abstract

A mere glance at the foundation of the sericulture industry to produce silk and the consequent establishment of the Silk Road to transport it; elucidates the significant role that this material has played in human history. Owing to its exceptional robustness, silk was introduced into medicine as a surgical suture approximately two millennia ago. During the last decades, silk has garnered attention as a possible source of biological-based materials that can be effectively used in regenerative medicine. Silk’s unique characteristics, like its low immunogenicity, suitable adhesive properties, exceptional tensile strength, perfect hemostatic properties, adequate permeability to oxygen and water, resistance to microbial colonization, and most importantly, excellent biodegradability; make it an outstanding choice for biomedical applications. Although there are many different types of silk in nature, Bombyx mori (B. mori) silk accounts for about 90% of global production and is the most thoroughly investigated and the most commonly used. Silk fibroin (SF) and silk sericin (SS) are the two main protein constituents of silk. SF has been manufactured in various morphologic forms (e.g. hydrogels, sponges, films, etc) and has been widely used in the biomedical field, especially as a scaffold in tissue engineering. Similarly, SS has demonstrated a vast potential as a suitable biomaterial in tissue engineering and regenerative medicine. Initial studies on SF and SS as wound dressings have shown encouraging results. This review aims to comprehensively discuss the potential role of silk proteins in refining wound healing and skin regeneration. © 2025 IOP Publishing Ltd. All rights, including for text and data mining, AI training, and similar technologies, are reserved.
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