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The Present and Future Disease Burden of Hepatitis C Virus Infections With Today's Treatment Paradigm - Volume 3 Publisher Pubmed



Sibley A1 ; Han KH2 ; Abourached A3 ; Lesmana LA4, 5 ; Makara M6 ; Jafri W7 ; Salupere R8 ; Assiri AM9 ; Goldis A10 ; Abaalkhail F11 ; Abbas Z12 ; Abdou A13 ; Al Braiki F14 ; Al Hosani F15 Show All Authors
Authors
  1. Sibley A1
  2. Han KH2
  3. Abourached A3
  4. Lesmana LA4, 5
  5. Makara M6
  6. Jafri W7
  7. Salupere R8
  8. Assiri AM9
  9. Goldis A10
  10. Abaalkhail F11
  11. Abbas Z12
  12. Abdou A13
  13. Al Braiki F14
  14. Al Hosani F15
  15. Al Jaberi K16
  16. Al Khatry M17
  17. Al Mulla MA15
  18. Al Quraishi H18
  19. Al Rifai A19
  20. Al Serkal Y20
  21. Alam A21
  22. Alavian SM22, 23
  23. Alashgar HI24
  24. Alawadhi S13
  25. Aldabal L25
  26. Aldins P26
  27. Alfaleh FZ27
  28. Alghamdi AS28
  29. Alhakeem R9
  30. Aljumah AA29
  31. Almessabi A14
  32. Alqutub AN28
  33. Alswat KA30
  34. Altraif I29
  35. Alzaabi M31
  36. Andrea N32
  37. Babatin MA28
  38. Baqir A33
  39. Barakat MT34
  40. Bergmann OM35
  41. Bizri AR36
  42. Blach S1
  43. Chaudhry A37
  44. Choi MS38
  45. Diab T39
  46. Djauzi S4
  47. El Hassan ES13
  48. El Khoury S40
  49. Estes C1
  50. Fakhry S41
  51. Farooqi JI42, 43
  52. Fridjonsdottir H44
  53. Gani RA4
  54. Ghafoor Khan A45
  55. Gheorghe L46
  56. Gottfredsson M47
  57. Gregorcic S48
  58. Gunter J1
  59. Hajarizadeh B49, 50
  60. Hamid S51
  61. Hasan I4
  62. Hashim A52
  63. Horvath G53
  64. Hunyady B54, 55
  65. Husni R56
  66. Jeruma A57, 58
  67. Jonasson JG59, 60
  68. Karlsdottir B61
  69. Kim DY2
  70. Kim YS62
  71. Koutoubi Z63
  72. Liakina V64, 65
  73. Lim YS66
  74. Love A47, 67
  75. Maimets M8
  76. Malekzadeh R68
  77. Maticic M48
  78. Memon MS69
  79. Merat S68
  80. Mokhbat JE70
  81. Mourad FH71
  82. Muljono DH72, 73
  83. Nawaz A74
  84. Nugrahini N75
  85. Olafsson S35
  86. Priohutomo S76
  87. Qureshi H77
  88. Rassam P40
  89. Razavi H1
  90. Razavishearer D1
  91. Razavishearer K1
  92. Rozentale B57, 58
  93. Sadik M69
  94. Saeed K78
  95. Salamat A79
  96. Sanai FM27
  97. Sanityoso Sulaiman A4
  98. Sayegh RA80
  99. Sharara AI71
  100. Siddiq M81, 82, 83
  101. Siddiqui AM83
  102. Sigmundsdottir G84, 85
  103. Sigurdardottir B61
  104. Speiciene D64
  105. Sulaiman A4, 86
  106. Sultan MA86
  107. Taha M87
  108. Tanaka J88
  109. Tarifi H89
  110. Tayyab G90, 91, 92
  111. Tolmane I57, 59
  112. Ud Din M92
  113. Umar M93, 94, 95
  114. Valantinas J64
  115. Videcnikzorman J48
  116. Yaghi C80, 82
  117. Yunihastuti E95
  118. Yusuf MA96
  119. Zuberi BF97
  120. Schmelzer JD1
Show Affiliations
Authors Affiliations
  1. 1. Center for Disease Analysis (CDA), Louisville, 80026, CO, United States
  2. 2. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
  3. 3. National Hepatitis Program, Ministry of Public Health, Beirut, Lebanon
  4. 4. Division of Hepatobiliary, Dept. of Int. Med., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia
  5. 5. Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia
  6. 6. Central Outpatient Clinic, Saint Laszlo Hospital, Budapest, Hungary
  7. 7. Aga Khan University, Karachi, Pakistan
  8. 8. Tartu University Hospital, University of Tartu, Tartu, Estonia
  9. 9. Department of Preventive Medicine, Ministry of Health, Riyadh, Saudi Arabia
  10. 10. Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania
  11. 11. Department of Liver and Small Bowel Transplantation, King Faisal Specialist Hospital and Research Centre, Alfaisal University, Riyadh, Saudi Arabia
  12. 12. Ziauddin University, Karachi, Pakistan
  13. 13. Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates
  14. 14. Abu Dhabi Health Services Company, Abu Dhabi, United Arab Emirates
  15. 15. Communicable Diseases Department, Health Authority Abu Dhabi, Abu Dhabi, United Arab Emirates
  16. 16. Health Regulation Division, Health Authority Abu Dhabi, Abu Dhabi, United Arab Emirates
  17. 17. Ras Al Khaimah Hospital, Ras Al Khaimah, United Arab Emirates
  18. 18. Dubai Health Authority, Dubai, United Arab Emirates
  19. 19. Mafraq Hospital, Abu Dhabi, United Arab Emirates
  20. 20. Hospitals Sector, Ministry of Health, Abu Dhabi, United Arab Emirates
  21. 21. Shaikh Zayed Hospital, Lahore, Pakistan
  22. 22. Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Tehran, Iran
  23. 23. Middle East Liver Diseases Centre, Tehran, Tehran, Iran
  24. 24. Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
  25. 25. Department of Pulmonary Medicine, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates
  26. 26. Infection Control Department, Pauls Stradins Clinical University Hospital, Riga, Latvia
  27. 27. Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia
  28. 28. Gastroenterology and Hepatology Unit, Medical Specialties Department, King Fahad Hospital, Riyadh, Saudi Arabia
  29. 29. King Abdulaziz Medical City and King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  30. 30. Department of Medicine, King Saud University Liver Disease Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  31. 31. Zayed Military Hospital, Abu Dhabi, United Arab Emirates
  32. 32. Daman National Health Insurance Company, Abu Dhabi, United Arab Emirates
  33. 33. Seyal Medical Centre, Multan, Pakistan
  34. 34. Health Authority Abu Dhabi, Abu Dhabi, United Arab Emirates
  35. 35. Division of Gastroenterology and Hepatology, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland
  36. 36. Division of Infectious Diseases, Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon
  37. 37. Gujranwala Liver Foundation, Siddiq Sadiq Hospital, Gujranwala, Pakistan
  38. 38. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
  39. 39. Al Ain Hospital, Al Ain, United Arab Emirates
  40. 40. Gastroenterology Department, Saint George Hospital, University of Balamand, Beirut, Lebanon
  41. 41. Abu Dhabi Police, Abu Dhabi, United Arab Emirates
  42. 42. Postgraduate Medical Institute, Khyber Medical University, Peshawar, Pakistan
  43. 43. Government Lady Reading Hospital, Peshawar, Pakistan
  44. 44. Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland
  45. 45. Department of Gastroenterology and Hepatology, Lady Reading Hospital, Peshawar, Pakistan
  46. 46. Center of Gastroenterology and Hepatology Fundeni Clinical Institute, Bucharest, Romania
  47. 47. Faculty of Medicine, School of Health Sciences, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland
  48. 48. Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre, Ljubljana, Slovenia
  49. 49. The Kirby Institute, University of New South Wales Australia, Sydney, NSW, Australia
  50. 50. The Australian Research Centre in Sex, Health and Society, la Trobe University, Melbourne, Vic., Australia
  51. 51. The Aga Khan University, Karachi, Pakistan
  52. 52. Liver Transplantation, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
  53. 53. Hepatology Center of Buda, Budapest, Hungary
  54. 54. Department of Gastroenterology, Somogy County Kaposi Mor Teaching Hospital, Kaposvar, Hungary
  55. 55. First Department of Medicine, University of Pecs, Pecs, Hungary
  56. 56. Lebanese American University Medical Center, Rizk Hospital, Beirut, Lebanon
  57. 57. Department of Hepatology, Infectology Center of Latvia, Riga, Latvia
  58. 58. Department of Infectology and Dermatology, Riga Stradins University, Riga, Latvia
  59. 59. Icelandic Cancer Registry, Reykjavik, Iceland
  60. 60. The Faculty of Medicine, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland
  61. 61. Division of Infectious Disease, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland
  62. 62. Department of Internal Medicine, Soon Chun Hyang University Bucheon Hospital, Bucheon, South Korea
  63. 63. Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates
  64. 64. Centre of Hepatology, Gastroenterology, and Dietetics, Faculty of Medicine, Vilnius University, Vilnius, Lithuania
  65. 65. Department of Biomechanics, Vilnius Gediminas Technical University, Vilnius, Lithuania
  66. 66. Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
  67. 67. Department of Virology, Landspitali - the National University Hospital of Iceland, Reykjavik, Iceland
  68. 68. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  69. 69. Asian Institute of Medical Science (AIMS), Hyderabad-Sindh, Pakistan
  70. 70. Divisions of Infectious Diseases and Clinical Microbiology, Lebanese American University Medical Center Rizk Hospital, Beirut, Lebanon
  71. 71. Division of Gastroenterology, American University of Beirut Medical Center, Beirut, Lebanon
  72. 72. Eijkman Institute for Molecular Biology, Jakarta, Indonesia
  73. 73. Department of Hepatitis and Emerging Infectious Diseases, University of Sydney, Sydney, NSW, Australia
  74. 74. Department of Gastroenterology, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan
  75. 75. Sub-Direct. for Gastrointestinal Infection, Diarrheal Dis., and Hepat., Direct. of Direct Transmitted Dis. Contr., Dis. Contr. and Environ. Hlth., Min. of Hlth, Jakarta, Indonesia
  76. 76. Direct. of Direct Transmitted Disease Control, Disease Control and Environmental Health, Ministry of Health, Jakarta, Indonesia
  77. 77. Pakistan Medical Research Council, Islamabad, Pakistan
  78. 78. Khawar Clinic, Sahiwal, Pakistan
  79. 79. Department of Gastroenterology, Military Hospital, Rawalpindi, Pakistan
  80. 80. Department of Hepatology and Gastroenterology, School of Medical Science, Saint Joseph University, Beirut, Lebanon
  81. 81. Jinnah Memorial Hospital, Rawalpindi, Pakistan
  82. 82. Yusra Medical College, Rawalpindi, Pakistan
  83. 83. Allama Iqbal Medical College, Lahore, Pakistan
  84. 84. Centre for Health Security and Communicable Disease Control, Direct. of Health in Iceland, Reykjavik, Iceland
  85. 85. Klinik Hati Prof. Ali Sulaiman, Jakarta, Indonesia
  86. 86. Health Funding Department, Enaya Insurance Company, Abu Dhabi, United Arab Emirates
  87. 87. Department of Medicine, Tawam Hospital, Al Ain, United Arab Emirates
  88. 88. Department of Epidemiology, Infect. Dis. Contr. and Prev., Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  89. 89. Pharmacy Department, Tawam Hospital, Al Ain, United Arab Emirates
  90. 90. Postgraduate Medical Institute, Lahore General Hospital, Lahore, Pakistan
  91. 91. Doctors Hospital and Medical Center, Lahore, Pakistan
  92. 92. Pakistan Society of Gastroenterology, Karachi, Pakistan
  93. 93. Department of Medicine, Rawalpindi Medical College, Rawalpindi, Pakistan
  94. 94. Department of Medicine, Holy Family Hospital, Rawalpindi, Pakistan
  95. 95. Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  96. 96. Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan
  97. 97. Dow Medical College, Karachi, Pakistan

Source: Journal of Viral Hepatitis Published:2015


Abstract

The total number, morbidity and mortality attributed to viraemic hepatitis C virus (HCV) infections change over time making it difficult to compare reported estimates from different years. Models were developed for 15 countries to quantify and characterize the viraemic population and forecast the changes in the infected population and the corresponding disease burden from 2014 to 2030. With the exception of Iceland, Iran, Latvia and Pakistan, the total number of viraemic HCV infections is expected to decline from 2014 to 2030, but the associated morbidity and mortality are expected to increase in all countries except for Japan and South Korea. In the latter two countries, mortality due to an ageing population will drive down prevalence, morbidity and mortality. On the other hand, both countries have already experienced a rapid increase in HCV-related mortality and morbidity. HCV-related morbidity and mortality are projected to increase between 2014 and 2030 in all other countries as result of an ageing HCV-infected population. Thus, although the total number of HCV countries is expected to decline in most countries studied, the associated disease burden is expected to increase. The current treatment paradigm is inadequate if large reductions in HCV-related morbidity and mortality are to be achieved. © 2015 John Wiley & Sons Ltd.
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