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Straightforward Approach Toward Dihydrothiazoles Via Intramolecular Bromocyclization Publisher



Sadatebrahimi SE1 ; Ganjizadeh Zarj M1 ; Moghimi S2 ; Yahyameymandi A1 ; Mahdavi M2 ; Arab S2 ; Shafiee A2 ; Foroumadi A2
Authors
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Authors Affiliations
  1. 1. School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Synthetic Communications Published:2015


Abstract

An intramolecular bromonium ion-assisted cyclization with sulfur as an internal nucleophile is described. Starting from benzoyl chlorides, this method provides an easy procedure for the synthesis of dihydrothiazole derivatives in moderate to good yields. © 2015 Taylor and Francis Group, LLC.