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Immunogenic Cell Death (Icd)-Inducers in Non-Small-Cell Lung Carcinoma (Nsclc): Current Knowledge and Future Perspective Publisher Pubmed



Kashefizadeh A1 ; Kazemizadeh H2
Authors
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Authors Affiliations
  1. 1. Department of Pulmonology, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Advanced Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Clinical and Translational Oncology Published:2023


Abstract

The prevalence of non-small-cell lung cancer (NSCLC) is rising every year all around the world. The interaction between cancer cells and the tumor microenvironment (TME) is a crucial factor in determining the development of human neoplasms. Organellar and cellular stress are induced during immunogenic cell death (ICD), a particularly functional response pattern. ICD is a separate but poorly characterized entity caused by various cancer treatments. The induction of ICD has the potential to change TME and the recruitment of tumor-infiltrating lymphocytes (TILs), and the coupling of ICD-inducers and other therapeutic approaches can have a synergistic role in boosting anticancer impacts. The purpose of this study is to review the studies in the field of NSCLC using ICD-inducers as a treatment strategy or as a combination therapy. This review provide for researches a better view of what has been done so far and the challenges they face in the future. © 2022, The Author(s), under exclusive licence to Federacion de Sociedades Espanolas de Oncologia (FESEO).
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