Development of an Electrochemical Sensor for Detection of Lupron As a Drug for Fibroids Treatment and Uterine Myoma in Pharmaceutical Waste and Water Sources Publisher



Movahed F¹ ; Ehymayed HM² ; Kalavi S³ ; Shahrtash SA⁴ ; Alhijazi AY⁵ ; Daemi A⁶ ; Mahmoud HMA⁷ ; Kashanizadeh MG⁸ ; Alsalamy AA⁹
Source: Journal of Food Measurement and Characterization Published:2024

Abstract

The creation of an electrochemical sensor based on a CeO2/CNT nanocomposite is presented in this study as a means of detecting Lupron (LPR) in water sources, pharmaceutical waste, and clinical samples. Leuprolide, marketed under the name LPR, is a drug that is frequently used to treat uterine myoma and fibroids. Accurate identification of lupron is essential for both guaranteeing efficacious therapy and keeping an eye on its existence in pharmaceutical waste and environmental sources, since it may present hazards to both human and environmental health. Comprehensive insights into the manufacture and application of the sensor were provided by the full synthesis of the CeO2/CNT nanocomposite and the electrode modification process. Characterizations using XRD, FT-IR, and TEM demonstrated the structural integrity and morphology of the CeO2/CNT nanocomposite, confirming its effective production. The CeO2/CNT nanocomposite modified electrode's electrochemical behavior for LPR showed a strong linear relationship between the peak current and LPR concentrations ranging from 20 to 2520 ng/ml. This resulted in low detection limits (LOD = 0.01 ng/ml) and high sensitivity (0.63398 µA/ng ml−1). The remarkable storage capacity and operational stability of the CeO2/CNT/GCE sensor were validated by long-term stability studies. Additionally, the sensor showed strong selectivity towards LPR even in the presence of structurally similar compounds, indicating that it is a suitable tool for selective detection in complex biological samples. The usefulness of the sensor for real-world applications was validated by analyzing real samples. The great potential of the CeO2/CNT nanocomposite to transform LPR detection is demonstrated in this study, along with its significance for the development of electrochemical sensing in critical applications such as environmental monitoring and clinical diagnostics. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.