Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Bioavailability, Biodistribution, and Toxicity of Fluorescent Metal Nanoclusters Publisher



Kefayat A1, 2, 3 ; Molaabasi F3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cancer Prevention Research Center, Department of Oncology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Luminescent Metal Nanoclusters: Synthesis, Characterization, and Applications Published:2022


Abstract

The anticipated effects and efficacy of metallic nanoclusters (NCs) in biomedical applications can only be achieved if they adequately reach the target organ, tissue, cells, or even intracellular organelles. Therefore, the bioavailability and biodistribution of these nanostructures can significantly affect their efficacy. A vast variety of coating and targeting decorations have been used to enhance metallic NCs’ efficacy by affecting their bioavailability and biodistribution. These decorations exhibit different strengths and weaknesses in different aspects. Also, one of the biggest obstacles against the clinical application of the nanostructures is some concerns about their toxicity. This chapter elaborately describes the recent research and advances in bioavailability, biodistribution, targeting, excretion, and the biocompatibility profiles of metallic NCs. © 2022 Elsevier Ltd. All rights reserved.
Related Docs
View other Related Docs
1. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
2. A Review of Bismuth-Based Nanoparticles and Their Applications in Radiosensitising and Dose Enhancement for Cancer Radiation Therapy, IET Nanobiotechnology (2023)
3. Antitumor Activity of Raloxifene-Targeted Poly(Styrene Maleic Acid)-Poly (Amide-Ether-Ester-Imide) Co-Polymeric Nanomicelles Loaded With Docetaxel in Breast Cancer-Bearing Mice, Investigational New Drugs (2018)
4. An Overview of the Intracellular Localization of High-Z Nanoradiosensitizers, Progress in Biophysics and Molecular Biology (2022)
5. Trastuzumab and Folic Acid Functionalized Gold Nanoclusters As a Dual-Targeted Radiosensitizer for Megavoltage Radiation Therapy of Human Breast Cancer, European Journal of Pharmaceutical Sciences (2020)
6. Biodegradable and Biocompatible Subcutaneous Implants Consisted of Ph-Sensitive Mebendazole-Loaded/Folic Acid-Targeted Chitosan Nanoparticles for Murine Triple-Negative Breast Cancer Treatment, Journal of Nanobiotechnology (2022)
7. Investigation of Different Targeting Decorations Effect on the Radiosensitizing Efficacy of Albumin-Stabilized Gold Nanoparticles for Breast Cancer Radiation Therapy, European Journal of Pharmaceutical Sciences (2019)
8. As1411 Aptamer-Targeted Gold Nanoclusters Effect on the Enhancement of Radiation Therapy Efficacy in Breast Tumor-Bearing Mice, Nanomedicine (2018)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (7)
Jaleh Varshosaz (3)
Other Related Docs
9. Peptide-Protected Metal Nanoclusters, Luminescent Metal Nanoclusters: Synthesis, Characterization, and Applications (2022)
10. Platinum Nanoparticles in Biomedicine: Preparation, Anti-Cancer Activity, and Drug Delivery Vehicles, Frontiers in Pharmacology (2022)
11. Recent Nanotheranostics Applications for Cancer Therapy and Diagnosis: A Review, IET Nanobiotechnology (2021)
12. Challenges and Opportunities of Using Fluorescent Metal Nanocluster-Based Colorimetric Assays in Medicine, ACS Omega (2023)
13. C-Phycocyanin: A Natural Product With Radiosensitizing Property for Enhancement of Colon Cancer Radiation Therapy Efficacy Through Inhibition of Cox-2 Expression, Scientific Reports (2019)
14. Efficacy of Co-Immunization With the Dna and Peptide Vaccines Containing Sycp1 and Acrbp Epitopes in a Murine Triple-Negative Breast Cancer Model, Human Vaccines and Immunotherapeutics (2021)
15. Ultra-Small But Ultra-Effective: Folic Acid-Targeted Gold Nanoclusters for Enhancement of Intracranial Glioma Tumors' Radiation Therapy Efficacy, Nanomedicine: Nanotechnology, Biology, and Medicine (2019)
16. Possible Health Risks Associated With Nanostructures in Food, Safety and Regulatory Issues of Nanoencapsulated Food Ingredients (2021)
17. Methods for Preparation of Metal Nanoparticles, Metal Nanoparticles: Synthesis and Applications in Pharmaceutical Sciences (2017)
18. Bacteria in Heavy Metal Remediation and Nanoparticle Biosynthesis, ACS Sustainable Chemistry and Engineering (2020)
19. Functionalized Silver and Gold Nanomaterials With Diagnostic and Therapeutic Applications, Pharmaceutics (2022)
20. A Drug Delivery System Based on Nanocomposites Constructed From Metal-Organic Frameworks and Mn3o4 Nanoparticles: Preparation and Physicochemical Characterization for Bt-474 and Mcf-7 Cancer Cells, Colloids and Surfaces B: Biointerfaces (2021)
21. Nanomaterials and Nanotechnology-Associated Innovations Against Viral Infections With a Focus on Coronaviruses, Nanomaterials (2020)
22. A Literature Review on Multimodality Molecular Imaging Nanoprobes for Cancer Detection, Polish Journal of Medical Physics and Engineering (2019)
23. Polyurethane-Nanolignin Composite Foam Coated With Propolis As a Platform for Wound Dressing: Synthesis and Characterization, Polymers (2021)
24. Exploring the Cancer-Testis Antigen Boris to Design a Novel Multi-Epitope Vaccine Against Breast Cancer Based on Immunoinformatics Approaches, Journal of Biomolecular Structure and Dynamics (2022)
25. Natural Resources for Sustainable Synthesis of Nanomaterials With Anticancer Applications: A Move Toward Green Nanomedicine, Environmental Research (2023)
26. Recent Metal Nanotheranostics for Cancer Diagnosis and Therapy: A Review, Diagnostics (2023)
27. Medical Imaging Modalities Using Nanoprobes for Cancer Diagnosis: A Literature Review on Recent Findings, Journal of Research in Medical Sciences (2019)
28. Assessment of Oxaliplatin-Loaded Iodine Nanoparticles for Chemoradiotherapy of Human Colorectal Cancer (Ht-29) Cells, Polymers (2022)
29. Skin Touch Effects of Gold Nanoparticles in Male Mice, Journal of Mazandaran University of Medical Sciences (2014)