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Multifunctional Plant Virus Nanoparticles for Targeting Breast Cancer Tumors Publisher



Shahgolzari M1 ; Dianatmoghadam H2 ; Yavari A3 ; Fiering SN4, 5 ; Hefferon K6
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Hamadan University of Medical Sciences, Hamadan, 6517838636, Iran
  2. 2. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  3. 3. Department of Biology, Payame Noor University, Tehran, 193954697, Iran
  4. 4. Department of Microbiology and Immunology, Dartmouth Geisel School of Medicine, Hanover, 03756, NH, United States
  5. 5. Norris Cotton Cancer Center, Dartmouth Geisel School of Medicine and Dartmouth-Hitchcock Medical Center, Lebanon, 03756, NH, United States
  6. 6. Virology Laboratory, Department of Cell & Systems Biology, University of Toronto, Toronto, M5S 3B2, ON, Canada

Source: Vaccines Published:2022


Abstract

Breast cancer treatment using plant-virus-based nanoparticles (PVNPs) has achieved considerable success in preclinical studies. PVNP-based breast cancer therapies include non-targeted and targeted nanoplatforms for delivery of anticancer therapeutic chemo and immune agents and cancer vaccines for activation of local and systemic antitumor immunity. Interestingly, PVNP platforms combined with other tumor immunotherapeutic options and other modalities of oncotherapy can improve tumor efficacy treatment. These applications can be achieved by encapsulation of a wide range of active ingredients and conjugating ligands for targeting immune and tumor cells. This review presents the current breast cancer treatments based on PVNP platforms. © 2022 by the authors.
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