Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Relationship Between Hypothyroidism and Preeclampsia in Pregnant Women in an Iranian Sample



Naghshineh E1 ; Saeidi Z2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2017

Abstract

Background: Hypothyroidism is common in Iran and preeclampsia is a pregnancy complications. Hypothyroidism has autoimmune base and one of the pathogenesis of preeclampsia is autoimmune disorder. This study aimed to evaluate the relationship between hypothyroidism and preeclampsia in pregnant women. Methods: This analytic descriptive cross-sectional study was done in Shahid Beheshti university hospital in Isfahan, Iran, in 2016. Simultaneously existence of hypothyroidism and preeclampsia and severity of preeclampsia and gestational age of pregnancy in time of delivery were evaluated in 298 pregnant women. Findings: The prevalence of preeclampsia in was 9.3% and 23.1% in euthyroid and hypothyroid women, respectively (P = 0.002) and a significant relationship was between hypothyroidism and severity of preeclampsia (P = 0.003). Preterm delivery was seen in 18.4% and 25.0% of euthyroid and hypothyroid women, respectively. However, preterm delivery was more in hypothyroid women; but there was no significant correlation between hypothyroidism and time of delivery (P = 0.440). There was no correlation between hypothyroidism and body weight (P = 0.410). First minute Apgar score in neonates of hypothyroid women was less than neonates of euthyroid women (P = 0.047); but fifth minute Apgar score had no significant difference (P = 0.110). Conclusion: This study showed that hypothyroidism can increase the risk of creation and severity of preeclampsia. So, diagnosis and treatment of hypothyroidism can decrease complications of pregnancy such as preeclampsia. © 2017, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Relative Frequency of Thyroid Disorders in Pregnant Women at a Maternity Clinic in Isfahan, Iran, Journal of Isfahan Medical School (2012)
2. Prevalence of Autoimmune Thyroiditis in Patients With Polycystic Ovary Syndrome, Archives of Gynecology and Obstetrics (2012)
3. Parental Consanguinity Among Parents of Neonates With Congenital Hypothyroidism in Isfahan, Eastern Mediterranean Health Journal (2007)
4. Prevalence of Transient Congenital Hypothyroidism in Central Part of Iran, Journal of Research in Medical Sciences (2013)
5. The Role of Maternal Tsh Receptor Blocking Antibody in the Etiology of Congenital Hypothyroidism in Isfahan, Journal of Isfahan Medical School (2011)
6. Congenital Hypothyroidism in Different Cities of the Isfahan Province: A Descriptive Retrospective Study, Journal of Education and Health Promotion (2019)
7. The Role of Maternal Thyroid Stimulating Hormone Receptor Blocking Antibodies in the Etiology of Congenital Hypothyroidism in Isfahan, Iran, International Journal of Preventive Medicine (2012)
8. Congenital Hypothyroidism; Is There Any Familial Component?, Journal of Isfahan Medical School (2009)
Experts (# of related papers)
View all Related Experts
Mahin Hashemipour (37)
Silva Hovsepian (29)
Other Related Docs
9. Prevalence of Congenital Hypothyroidism in Isfahan, Iran: Results of a Survey on 20,000 Neonates, Hormone Research (2004)
10. Thyroid Function Test Reference Ranges in the First Trimester of Gestation and Pregnancy Outcomes: Protocol and Preliminary Results for Cohort Population-Based Study Isfahan, Iran, Journal of Research in Medical Sciences (2018)
11. Prevalence of Pre-Pregnancy Risk Factors and Its Relationship With Preconception Care in Isfahan- Iran, International Journal of Pediatrics (2017)
12. The Incidence of Congenital Hypothyroidism and Its Determinants From 2012 to 2014 in Shadegan, Iran: A Case-Control Study, Epidemiology and health (2016)
13. Outcome of Congenitally Hypothyroid Screening Program in Isfahan: Iran From Prevention to Treatment, International Journal of Preventive Medicine (2010)
14. Thyroid Volume and Nodular and Diffuse Thyroid Diseases by Ultrasonography in Pregnant Women: A Case-Control Study, Journal of Research in Medical Sciences (2020)
15. The Descriptive Findings of Growth Status Among Children With Congenital Hypothyroidism Referred to Isfahan Endocrine and Metabolism Research Center, Journal of Isfahan Medical School (2012)
16. Prevalence of Permanent Congenital Hypothyroidism in Isfahan-Iran, International Journal of Preventive Medicine (2013)
17. Thyroid Function Abnormalities Among First-Degree Relatives of Iranian Congenital Hypothyroidism Neonates, Pediatrics International (2010)
18. Permanent and Transient Congenital Hypothyroidism in Isfahan-Iran, Journal of Medical Screening (2009)
19. The Prevalence of Thyroid Dysfunction in an Iodine-Sufficient Area in Iran, Archives of Iranian Medicine (2009)
20. Effect of Diagnostic and Treatment Factors on Growth Development of Children With Congenital Hypothyroidism: A Prospective Longitudinal Study, Iranian Journal of Endocrinology and Metabolism (2015)
21. Thyroid Dysfunction in Very-Low-Birth-Weight Premature Neonates: A Systematic Review of Published Evidence, Journal of Isfahan Medical School (2017)
22. Different Aspects of Kidney Function in Well-Controlled Congenital Hypothyroidism, JCRPE Journal of Clinical Research in Pediatric Endocrinology (2012)
23. Dietary Determinants of Pregnancy Induced Hypertension in Isfahan, Journal of Research in Medical Sciences (2008)
24. Association of Factor V Leiden Deficiency With Preeclampsia, Eclampsia in the Pregnant Women, Journal of Babol University of Medical Sciences (2014)
25. A Comprehensive Home-Care Program for Health Promotion of Mothers With Preeclampsia: Protocol for a Mixed Method Study, Reproductive Health (2019)
26. Aspirin Administration From Early Pregnancy Versus Initiation After 11 Weeks of Gestation for Prevention of Pre-Eclampsia in Highrisk Pregnant Women: Study Protocol for Randomized Controlled Trial, International Journal of Reproductive BioMedicine (2024)
27. Rate of Recalls in Congenital Hypothyroidism Based Upon a Regional Survey in Isfahan, Iran, Using Serum T4 and Tsh Analyses: Comparison of Two Different Recall Methods, Hormone Research (2005)
28. Isfahan Thyroid Cohort Study (Itcs), Archives of Iranian Medicine (2021)
29. Incidence of Thyroid Dysfunction in an Iranian Adult Population: The Predictor Role of Thyroid Autoantibodies: Results From a Prospective Population-Based Cohort Study, European Journal of Medical Research (2017)
30. Guideline for the Treatment of Hypothyroidism in Prematurity, International Journal of Preventive Medicine (2021)
31. Spatial Distribution of Congenital Hypothyroidism, Archives of Iranian Medicine (2021)
32. Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis, Thyroid (2024)
33. The Role of Ultrasonography in Primary Congenital Hypothyroidism, Journal of Research in Medical Sciences (2011)
34. Survey of Pregnacy Induced Hypertention in Pregnant Women in Isfahan University of Medical Sciences Hospitals, Journal of Isfahan Medical School (2011)
35. The Association Between Familial and Environmental Factors and Prevalence of Congenital Hypothyroidism in Center of Iran, Environmental Science and Pollution Research (2021)
36. [Tc]-99M Thyroid Scintigraphy in Congenital Hypothyroidism Screening Program, Journal of Tropical Pediatrics (2006)
37. Comparison of the Mean Level of C3 & C4 Complements in Pre-Eclamptic Patients and Normal Pregnancy, Journal of Isfahan Medical School (2007)
38. Comparison of Urine and Milk Iodine Concentration Among Congenitally Hypothyroid Neonates and Their Mothers and a Control Group, Iranian Journal of Endocrinology and Metabolism (2009)
39. Maternal Mortality in Isfahan Province 2001-2006, Journal of Medical Sciences (2007)
40. The Relation Between Serum and Filter Paper Thyroid-Stimulating Hormone Levels in Neonates With Congenital Hypothyroidism, Journal of Isfahan Medical School (2012)
41. Usefulness of Ultrasonography in the Diagnosis of the Etiology of Congenital Hypothyroidism Comparing With Radioisotope Scanning, Iranian Journal of Endocrinology and Metabolism (2009)
42. The Relationship Between Metabolic Syndrome Criteria and Preeclampsia in Primigravid Women, Iranian Journal of Nursing and Midwifery Research (2015)
43. Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-Analysis, Journal of Clinical Endocrinology and Metabolism (2024)
44. The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein a and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency, Advanced Biomedical Research (2023)
45. Association of Thyroid Function Test Values With Prepregnancy Body Mass Index and Gestational Weight Gain: A Systematic Review of Literature Reviews, Iranian Journal of Nursing and Midwifery Research (2025)
46. Sonographic Assessment of Congenitally Hypothyroid Children in Iran, Endokrynologia Polska (2010)
47. Frequency of Thyroid Function Disorders Among a Population of Very-Low-Birth-Weight Premature Infants, Iranian Journal of Neonatology (2016)
48. The Association Between Serum Tsh Concentration Whithin the Normal Range and Nutritional Status in Euthyroid Pregnant Women at the First Trimester of Gestation, Journal of Research in Medical Sciences (2021)
49. Mothers and Their Children’S Health (Match): A Study Protocol for a Population‐Based Longitudinal Cohort, BMC Pregnancy and Childbirth (2021)
50. Screening of Congenital Hypothyroidism in Preterm, Low Birth Weight and Very Low Birth Weight Neonates: A Systematic Review, Pediatrics and Neonatology (2018)