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Current Status and Perspectives Regarding Lna-Anti-Mir Oligonucleotides and Microrna Mir-21 Inhibitors As a Potential Therapeutic Option in Treatment of Colorectal Cancer Publisher Pubmed



Nedaeinia R1, 2 ; Avan A3, 4 ; Ahmadian M5 ; Nia SN6 ; Ranjbar M1 ; Sharifi M7 ; Goli M8 ; Piroozmand A9 ; Nourmohammadi E2 ; Manian M10 ; Ferns GA11 ; Ghayourmobarhan M3, 4 ; Salehi R7
Authors
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Authors Affiliations
  1. 1. Deputy of Food and Drug, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Student Research Committee, Department of medical biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Gastroentrology, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Agricultural engineering and Weed science, Shiraz Branch, Islamic Azad University, Shiraz, Iran
  7. 7. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Food Science and Technology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
  9. 9. School of Medicine, Kashan University of Medical Sciences, Autoimmune Diseases Research Center, Kashan, Iran
  10. 10. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  11. 11. Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, BN1 9PH, Sussex, United Kingdom

Source: Journal of Cellular Biochemistry Published:2017


Abstract

Colorectal cancer (CRC) is among the leading causes of cancer-related death, principally due to its metastatic spread and multifactorial chemoresistance. The therapeutic failure can also be explained by inter- or intra-tumor genetic heterogeneity and tumor stromal content. Thus, the identification of novel prognostic biomarkers and therapeutic options are warranted in the management of CRC patients. There are data showing that microRNA-21 is elevated in different types of cancer, particularly colon adenocarcinoma and that this is association with a poor prognosis. This suggests that microRNA-21 may be of value as a potential therapeutic target. Furthermore, locked nucleic acid (LNA)-modified oligonucleotides have recently emerged as a therapeutic option for targeting dysregulated miRNAs in cancer therapy, through antisense-based gene silencing. Further work is required to identify innovative anticancer drugs that improve the current therapy either through novel combinatorial approaches or with better efficacy than conventional drugs. We aimed to provide an overview of the preclinical and clinical studies targeting key dysregulated signaling pathways in CRC as well as the therapeutic application of LNA-modified oligonucleotides, and miR inhibitors in the treatment of CRC patients. J. Cell. Biochem. 118: 4129–4140, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.
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