Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Role of Long Non-Coding Rnas in the Pathogenesis of Essential Hypertension Publisher



Azizidoost S1 ; Khojasteh Pour F2 ; Najafi S3 ; Ghaedrahmati F4 ; Nazeri Z5 ; Dayer D6 ; Shabani Z7 ; Farzaneh M8 ; Nasrolahi A6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Center for Cerebrovascular Research, University of California, San Francisco, CA, United States
  8. 8. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Current Signal Transduction Therapy Published:2024


Abstract

Hypertension, a condition characterized by elevated blood pressure, poses a significant medical risk, particularly in relation to the development of cardiovascular disease. The pathogenesis of hypertension can be influenced by a combination of genetic and environmental factors. Recent scientific studies have shed light on the involvement of long-non-coding RNAs (lncRNAs) in various diseases, including pulmonary arterial and essential hypertension. These lncRNAs have been found to play crucial roles at the transcriptional, post-transcriptional, and post-translational levels. By targeting endothelial cell proliferation, migration, apoptosis, and angiogenesis, lncRNAs can induce dysfunction in arterial endothelial cells, contributing to the progression of hypertension-related pathological events. Therefore, the abnormal expression of lncRNAs has emerged as a significant factor in the understanding of essential hypertension and its associated mechanisms. To further our understanding, we conducted a comprehensive review focusing on unraveling the functional roles of lncRNAs in essential hypertension. © 2024 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Ncrnas and Polyphenols: New Therapeutic Strategies for Hypertension, RNA Biology (2022)
2. New Insights Into the Long Non-Coding Rnas Dependent Modulation of Heart Failure and Cardiac Hypertrophy: From Molecular Function to Diagnosis and Treatment, Current Medicinal Chemistry (2024)
3. The Mechanisms of Long Non-Coding Rna-Xist in Ischemic Stroke: Insights Into Functional Roles and Therapeutic Potential, Molecular Neurobiology (2024)
4. A Comprehensive Review of the Role of Lncrnas in Gastric Cancer (Gc) Pathogenesis, Immune Regulation, and Their Clinical Applications, Pathology Research and Practice (2023)
5. Non-Invasive Diagnosis of Early-Onset Coronary Artery Disease Based on Cell Type-Specific Gene Expression Analyses, Biomedicine and Pharmacotherapy (2018)
6. The Functions of Long Non-Coding Rna (Lncrna)-Malat-1 in the Pathogenesis of Renal Cell Carcinoma, BMC Nephrology (2023)
7. Role of Long Noncoding Rnas in Pathological Cardiac Remodeling After Myocardial Infarction: An Emerging Insight Into Molecular Mechanisms and Therapeutic Potential, Biomedicine and Pharmacotherapy (2024)
8. Long Noncoding Rnas in Gastric Cancer Carcinogenesis and Metastasis, Briefings in Functional Genomics (2017)
Experts (# of related papers)
View all Related Experts
Mehran Sharifi (2)
Mohammadreza Sharifi (2)
Other Related Docs
9. Molecular Mechanism of Lncrnas in Regulation of Breast Cancer Metastasis; a Comprehensive Review, Cell Biochemistry and Biophysics (2025)
10. An Updated Review of Contribution of Long Noncoding Rna-Neat1 to the Progression of Human Cancers, Pathology Research and Practice (2023)
11. Modulation of Long Non-Coding Rnas and Micrornas by Quercetin As a Potential Therapeutical Approach in Cancer: A Comprehensive Review, Current medicinal chemistry (2025)
12. Multiple Function of Lncrna Malat1 in Cancer Occurrence and Progression, Chemical Biology and Drug Design (2023)
13. Emerging Roles for Lncrna-Neat1 in Colorectal Cancer, Cancer Cell International (2022)
14. Apoptosis and Myocardial Infarction: Role of Ncrnas and Exosomal Ncrnas, Epigenomics (2023)
15. Functional Roles of Lncrnas in Recurrent Pregnancy Loss: A Review Study, International Journal of Fertility and Sterility (2023)
16. Long Non-Coding Rnas and Melanoma: From Diagnosis to Therapy, Pathology Research and Practice (2023)
17. In Silico Identification and in Vitro Evaluation of Mrps30-Dt Lncrna and Mrps30 Gene Expression in Breast Cancer, Cancer Reports (2024)
18. Role of Micrornas in Pulmonary Hypertension, Horizons in World Cardiovascular Research (2022)
19. Modulation of Long Non-Coding Rnas by Resveratrol As a Potential Therapeutic Approach in Cancer: A Comprehensive Review, Pathology Research and Practice (2023)
20. Exploring Potential Roles of Long Non-Coding Rnas in Cancer Immunotherapy: A Comprehensive Review, Frontiers in Immunology (2024)
21. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney, Hypertension (2017)
22. Induction of Apoptosis and Necrosis in Human Acute Erythroleukemia Cells by Inhibition of 47Tlong Non-Coding Rna Pvt1, Molecular Biology Research Communications (2018)
23. Tgf-Β and Wnt Signaling Pathways in Cardiac Fibrosis: Non-Coding Rnas Come Into Focus, Cell Communication and Signaling (2020)