The Role of Long Non-Coding Rnas in the Pathogenesis of Essential Hypertension Publisher



Azizidoost S¹ ; Khojasteh Pour F² ; Najafi S³ ; Ghaedrahmati F⁴ ; Nazeri Z⁵ ; Dayer D⁶ ; Shabani Z⁷ ; Farzaneh M⁸ ; Nasrolahi A⁶
Source: Current Signal Transduction Therapy Published:2024

Abstract

Hypertension, a condition characterized by elevated blood pressure, poses a significant medical risk, particularly in relation to the development of cardiovascular disease. The pathogenesis of hypertension can be influenced by a combination of genetic and environmental factors. Recent scientific studies have shed light on the involvement of long-non-coding RNAs (lncRNAs) in various diseases, including pulmonary arterial and essential hypertension. These lncRNAs have been found to play crucial roles at the transcriptional, post-transcriptional, and post-translational levels. By targeting endothelial cell proliferation, migration, apoptosis, and angiogenesis, lncRNAs can induce dysfunction in arterial endothelial cells, contributing to the progression of hypertension-related pathological events. Therefore, the abnormal expression of lncRNAs has emerged as a significant factor in the understanding of essential hypertension and its associated mechanisms. To further our understanding, we conducted a comprehensive review focusing on unraveling the functional roles of lncRNAs in essential hypertension. © 2024 Bentham Science Publishers.