Biosynthesis of Lead Oxide and Cerium Oxide Nanoparticles and Their Cytotoxic Activities Against Colon Cancer Cell Line Publisher



Nazaripour E^{1, 2} ; Mousazadeh F² ; Doosti Moghadam M³ ; Najafi K^{2, 4} ; Borhani F⁵ ; Sarani M⁶ ; Ghasemi M² ; Rahdar A⁷ ; Iravani S⁸ ; Khatami M^{2, 9} Show Affiliations
Source: Inorganic Chemistry Communications Published:2021

Abstract

Green synthesis of nanoparticles is considered as a potential and efficient choice compared to chemical and physical ways for the preparation of nanoparticles due to important advantages such as eco-friendliness, safety, simplicity, cost-effectiveness, up-scalable potentials, and also is according bioethics principles. In this study, cerium oxide (CeO2) and lead oxide (PbO) nanoparticles were prepared in a green approach by aqueous extract of Prosopis fracta fruit. The structure and morphology of prepared nanoparticles were confirmed using PXRD, UV–Vis, FT-IR, TEM, EDX, and FESEM analyses. The cytotoxic activity of PbO and CeO2 nanoparticles was studied on colon (HT-29) cancer cell lines. Based on the obtained results, PbO and CeO2 nanoparticles were non-toxic in below concentration of 500 and 62.5 µg/mL, respectively. Notably, these nanoparticles can play vital roles in biological assays, and further studies should be performed on their cytotoxic evaluations, in vivo. © 2021 Elsevier B.V.