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Trends in the Burden and Determinants of Hypertensive Heart Disease in the Eastern Mediterranean Region, 1990–2019: An Analysis of the Global Burden of Disease Study 2019 Publisher



Mansouri A1 ; Khosravi A1 ; Mehrabanizeinabad K2 ; Kopec JA3, 4 ; Adawi KII5 ; Lui M3 ; Abdul Rahim HF5 ; Anwar W6 ; Fadhil I7 ; Sulaiman K8 ; Bazargani N9 ; Saade G10 ; Farhan HA11 ; Almahmeed W12 Show All Authors
Authors
  1. Mansouri A1
  2. Khosravi A1
  3. Mehrabanizeinabad K2
  4. Kopec JA3, 4
  5. Adawi KII5
  6. Lui M3
  7. Abdul Rahim HF5
  8. Anwar W6
  9. Fadhil I7
  10. Sulaiman K8
  11. Bazargani N9
  12. Saade G10
  13. Farhan HA11
  14. Almahmeed W12
  15. Bokhari SS13
  16. Hassen N3, 4
  17. Alandejani A3
  18. Shirani S14
  19. Abdin A15
  20. Manla Y12, 16
  21. Johnson C17
  22. Stark B17
  23. Roth GA18
  24. Mokdad AH17, 19
  25. Shariful Islam SM20
  26. Sarrafzadegan N3, 21
Show Affiliations
Authors Affiliations
  1. 1. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. School of Population & Public Health, University of British Columbia, Vancouver, Canada
  4. 4. Arthritis Research Canada, Vancouver, Canada
  5. 5. Department of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar
  6. 6. Community Medicine Department, Faculty of Medicine, Ain Shams University, Egypt and Armed Forces College of Medicine (AFCM), Egypt
  7. 7. Eastern Mediterranean Non-Communicable Disease Alliance, Kuwait
  8. 8. National Heart Canter, Royal Hospital, Oman
  9. 9. Department of Cardiology, Dubai Hospital, Dubai, United Arab Emirates
  10. 10. Department of Cardiology, Bellevue Medical Center, Beirut, Lebanon
  11. 11. Scientific Council of Cardiology, Iraqi Board for Medical Specializations, Baghdad Heart Center, Baghdad, Iraq
  12. 12. Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, United Arab Emirates
  13. 13. Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
  14. 14. Department of Cardiology, Tehran University of Medical Science, Dr Ali Shariati Hospital, Tehran, Iran
  15. 15. Syrian Cardiovascular Association, Damascus, Syrian Arab Republic
  16. 16. Faculty of Medicine, Aleppo University, Aleppo, Syrian Arab Republic
  17. 17. Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States
  18. 18. Division of Cardiology, Department of Medicine, University of Washington, Seattle, United States
  19. 19. Department of Health Metrics Sciences, University of Washington, Seattle, United States
  20. 20. Institute for Physical Activity and Nutrition, Deakin University, Melbourne, Australia
  21. 21. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: eClinicalMedicine Published:2023


Abstract

Background: Hypertensive heart disease (HHD), one of the end-organ damage consequences of hypertension, is an important public health issue worldwide. Data on the HHD burden in the Eastern Mediterranean region (EMR) are scarce. We aimed to investigate the burden of HHD in the EMR, its member countries, and globally from 1990 to 2019. Methods: We used 2019 Global Burden of Disease (GBD) data to report the HHD age-standardised prevalence, disability adjusted life years (DALYs), years of life lost (YLLs), and mortality, as well as HHD risk factors attribution percent with their 95% uncertainty interval (UI). Global data are reported alongside EMR data, and its 22 respective countries. We compared the burden of HHD by socio-demographic index (SDI), sex, age groups, and countries. Findings: The age-standardised prevalence rate (per 100,000 population) of HHD was higher in the EMR (281.7; 95% UI: 204.5–383.4) in 2019, compared with the global prevalence (233.8; 95% UI: 170.5–312.9). The EMR age-standardised DALYs (per 100,000 population) for HHD in 2019 was 561.9 (361.0–704.1), compared with 268.2 (204.6–298.1) at the global level. There was an increase in HHD prevalence, reduction in mortality, and DALYs between 1990 and 2019 (4.01%, −7.6%, and −6.5%, respectively) in EMR. Among EMR countries, the highest versus lowest rates of age-standardised prevalence, mortality, and DALYs in 2019 [estimate (95% UI)] were in Jordan [561.62 (417.9–747.6)] versus Saudi Arabia [94.9 (69.5–129.0)]; Afghanistan [74.5 (23.7–112.3)] versus Saudi Arabia [4.3 (3.3–5.9)]; and Afghanistan [1374.1 (467.2–2020.7)] versus Qatar [87.11 (64.40–114.29)], respectively. Interpretation: HHD remains a significant problem in the EMR, with a higher burden than global levels. Serious efforts toward high-quality management and prevention are strongly recommended. Based on this study, our recommendation for the EMR is to adopt effective preventive strategies. For example, promoting healthy dietary patterns and prompt screening for undiagnosed HTN in public places, promoting regular blood pressure measurements at home, and creating community awareness about early detection of HTN. Funding: None. © 2023 The Authors
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