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Iron Oxyhydroxide Nanoparticles: Green Synthesis and Their Cytotoxicity Activity Against A549 Human Lung Adenocarcinoma Cells Publisher



Sadeghi H1 ; Alijani HQ2 ; Hashemishahraki S3 ; Naderifar M4 ; Rahimi SS2 ; Zadeh FA5 ; Iravani S6 ; Haghighat M7 ; Khatami M8
Authors
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Authors Affiliations
  1. 1. Department of Chemical and Petroleum Engineering, Sharif University of Technology, 11155-9465 Azadi Avenue, Tehran, Iran
  2. 2. Department of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran
  3. 3. Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
  4. 4. Faculty of Nursing and Midwifery, Zabol University of Medical Sciences, Zabol, Iran
  5. 5. Department of Surgery, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  6. 6. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Behbahan Faculty of Medical Sciences, Behbahan, Iran
  8. 8. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Rendiconti Lincei Published:2022


Abstract

Iron oxyhydroxide (α-FeOOH, Goethite) is one of the most thermodynamically stable iron oxides and a widespread soil mineral. In this study, a mixture of two phenolic extracts of rosemary and Echinacea was utilized as stabilizing and reducing agents for the synthesis of Goethite (FeOOH) nanoparticles without utilizing harmful toxic solvents. The resulting nanoparticles were characterized by X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM)-energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), vibrating-sample magnetometer (VSM), thermogravimetry/differential thermal analysis (TG/DTA), and Brunauer–Emmett-Teller (BET). MTT assay was applied for evaluating the possible toxicity of the nanoparticles against A549 human lung adenocarcinoma cells. © 2022, The Author(s), under exclusive licence to Accademia Nazionale dei Lincei.
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