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Biosynthesis of Zn-Doped Cufe2o4 Nanoparticles and Their Cytotoxic Activity Publisher Pubmed



Darvish M1 ; Nasrabadi N2 ; Fotovat F3 ; Khosravi S4 ; Khatami M5 ; Jamali S6 ; Mousavi E7 ; Iravani S8 ; Rahdar A9
Authors
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Authors Affiliations
  1. 1. Department of Endodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Department of Endodontics, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran
  3. 3. Department of Prosthodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
  4. 4. Department of Orthodontics, School of Dentistry, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  6. 6. Department of Endodontics, Stomatological Hospital, College of Stomatology, Xi’an Jiaotong University, Shaanxi, 710004, China
  7. 7. Dental Sciences Research Center, Department of Endodontics, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran
  8. 8. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  9. 9. Department of Physics, University of Zabol, P. O. Box. 98613-35856, Zabol, Iran

Source: Scientific Reports Published:2022


Abstract

Zn-doped CuFe2O4 nanoparticles (NPs) were eco-friendly synthesized using plant extract. These nanoparticles were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy and thermal gravimetric analysis (TGA). SEM image showed spherical NPs with size range less than 30 nm. In the EDS diagram, the elements of zinc, copper, iron, and oxygen are shown. The cytotoxicity and anticancer properties of Zn-doped CuFe2O4 NPs were evaluated on macrophage normal cells and A549 lung cancer cells. The cytotoxic effects of Zn-doped CuFe2O4 and CuFe2O4 NPs on A549 cancer cell lines were analyzed. The Zn-doped CuFe2O4 and CuFe2O4 NPs demonstrated IC50 values 95.8 and 278.4 µg/mL on A549 cancer cell, respectively. Additionally, Zn-doped CuFe2O4 and CuFe2O4 NPs had IC80 values of 8.31 and 16.1 µg/mL on A549 cancer cell, respectively. Notably, doping Zn on CuFe2O4 NPs displayed better cytotoxic effects on A549 cancer cells compared with the CuFe2O4 NPs alone. Also spinel nanocrystals of Zn-doped CuFe2O4 (~ 13 nm) had a minimum toxicity (CC50 = 136.6 µg/mL) on macrophages J774 Cell Line. © 2022, The Author(s).
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