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The Effects of 6-Gingerol on Reproductive Improvement, Liver Functioning and Cyclooxygenase-2 Gene Expression in Estradiol Valerate – Induced Polycystic Ovary Syndrome in Wistar Rats Publisher Pubmed



Pournaderi PS1 ; Yaghmaei P1 ; Khodaei H2 ; Noormohammadi Z1 ; Hejazi SH3
Authors
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Authors Affiliations
  1. 1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Animal Sciences, Islamic Azad University, Golpayegan Branch, Isfahan, Iran
  3. 3. Skin Disease and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Biochemical and Biophysical Research Communications Published:2017


Abstract

6-Gingerol is the major pungent ingredient of ginger with anti-inflammatory and antioxidant properties. In this study, we evaluate the effects of 6-gingerol on the biochemical parameters and ovarian histological improvements in estradiol valerate (EV) induced PCOS rats. Thirty six female Wistar rats were divided into 4 groups: control, received normal diet, PCOS control, received 4 mg/kg EV injection for 28 days and two experimental groups, received an EV injection for 28 days and followed by 6-gingerol (200 μg/kg and 400 μg/kg) for 14 days. The administration of EV led to increase body and ovarian weights, abnormality in serum sex steroid profile, decrease in antioxidant activity and increase in COX-2 gene expression. 6-gingerol treatments, particularly the 400 μg/kg dose, markedly attenuated these alterations. 6-gingerol showed beneficial effects in the EV induced PCOS rats via decreased expression of COX-2, restored biochemical parameters to normal and decreased of cysts in the ovaries. © 2017 Elsevier Inc.
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