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Effect of Cinnamon on Migraine Attacks and Inflammatory Markers: A Randomized Double-Blind Placebo-Controlled Trial Publisher Pubmed



Zareie A1 ; Sahebkar A2, 3 ; Khorvash F4 ; Bagherniya M1 ; Hasanzadeh A5 ; Askari G1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Phytotherapy Research Published:2020


Abstract

Migraine is the most common type of primary headaches. Increased levels of interleukin-6 (IL-6), calcitonin-gene-related peptide (CGRP) and nitric oxide (NO) lead to inflammation and neurogenic pain. Cinnamon has anti-inflammatory and neuroprotective properties. Thus, the aim of this study was to assess the effect of cinnamon on migraine attacks and inflammatory status. Fifty patients with migraine were randomized to receive either cinnamon powder (three capsules/day each containing 600 mg of cinnamon) or three placebo capsules/day each containing 100 mg of corn starch (control group) for 2 months. Serum levels of IL-6, CGRP and NO were measured at baseline and at the end of the study. The frequency, severity and duration of pain attacks were also recorded using questionnaire. Serum concentrations of IL-6 and NO were significantly reduced in the cinnamon group compared with the control group (p <.05). However, serum levels of CGRP remained unchanged in both groups. The frequency, severity and duration of migraine attacks were significantly decreased in the cinnamon group compared with the control group. Cinnamon supplementation reduced inflammation as well as frequency, severity and duration of headache in patients with migraine. Cinnamon could be regarded as a safe supplement to relieve pain and other complications of migraine. © 2020 John Wiley & Sons, Ltd.
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