Different Genotype of Rs3130932 Single Nucleotide Polymorphism Between Gastric Cancer Patients and Normal Subjects Publisher Pubmed



Shahhoseini Z¹ ; Jeivad F² ; Ahangar N¹ ; Abediankenari S³ Show Affiliations
Source: Journal of Gastrointestinal Cancer Published:2017

Abstract

Purpose: Octamer binding transcription factor B gene (OCT4) is responsible for development and self-renewal maintenance of embryonic stem cells. The rs3130932 single nucleotide polymorphism (SNP) may play a role in tumor genesis. Because of high prevalence of gastric cancer in north of Iran, this study was investigated role of rs3130932 polymorphism and stomach cancer. Methods: Blood samples were collected from 100 informed gastric cancer patients and 100 age and sex-matched healthy individuals, and were genotyped for the presence of rs3130932G allele by ssp PCR. Results: The mean age of participant (n = 200) was 67.83 ± 10.878 years. In genotyping and allelic analysis, TG genotype increased 66.147 times more likely to develop stomach cancer than the TT genotype, and disease risk increases 140.496 times more in GG genotype in comparison with TT genotype. Conclusion: This study clearly emphasis on different genetic profile in this population and show that the rs3130932G allele and odds of gastric cancer are related to each other in northern of Iran. © 2016, Springer Science+Business Media New York.