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Decoration of Graphene Oxide Nanosheets With Carboxymethylcellulose Hydrogel, Silk Fibroin and Magnetic Nanoparticles for Biomedical and Hyperthermia Applications Publisher



Ghafori Gorab M1 ; Aliabadi HAM2 ; Kashtiaray A1 ; Mahdavi M3 ; Bani MS4 ; Etminan A5 ; Salehpour N6 ; Eivazzadehkeihan R1 ; Maleki A1
Authors
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Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  5. 5. School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
  6. 6. Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran

Source: Nanoscale Advances Published:2022


Abstract

In this study, an efficient nanobiocomposite based on graphene oxide (GO), carboxymethylcellulose (CMC) hydrogel, silk fibroin (SF), and Fe3O4 nanoparticles was synthesized. For this purpose and in order to provide a suitable scaffold for the nanobiocomposite, GO was functionalized with a CMC hydrogel via covalent bonding. In the next step, SF was added to the synthesized structure to increase biocompatibility and biodegradability. Fe3O4 was added into the structure by an in situ process and the GO-CMC hydrogel/SF/Fe3O4 nanobiocomposite was synthesized. The synthesized structure was evaluated in terms of toxicity and hemocompatibility and finally, it was used in the hyperthermia technique. This nanocomposite did not destroy healthy HEK293T cells after 48 h and 72 h, while it did annihilate BT549 cancer cells. The GO-CMC hydrogel/SF/Fe3O4 nanobiocomposite has EC50 values of 0.01466 and 0.1415 against HEK293T normal cells and BT549 cancer cells, respectively (after 72 h). The nanocomposite has good potential in hyperthermia applications and at a concentration and a frequency of 1 mg mL−1 and 400 kHz it has a SAR of 67.7 W g−1 © 2023 RSC.