Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern

Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern Publisher Pubmed

Salehi M¹ ; Ahmadikia K² ; Mahmoudi S³ ; Kalantari S⁴ ; Jamalimoghadamsiahkali S⁵ ; Izadi A² ; Kord M² ; Dehghan Manshadi SA¹ ; Seifi A¹ ; Ghiasvand F¹ ; Khajavirad N⁶ ; Ebrahimi S⁴ ; Koohfar A¹ ; Boekhout T^{7, 8} Show All Authors

Salehi M¹
Ahmadikia K²
Mahmoudi S³
Kalantari S⁴
Jamalimoghadamsiahkali S⁵
Izadi A²
Kord M²
Dehghan Manshadi SA¹
Seifi A¹
Ghiasvand F¹
Khajavirad N⁶
Ebrahimi S⁴
Koohfar A¹
Boekhout T^{7, 8}
Khodavaisy S²

Show Affiliations

1. Department of Infectious Diseases and Tropical Medicine, Imam Khomeini Hospital complex, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medical Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4. Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran
5. Department of Infectious Diseases and Tropical Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands
8. Institute of Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam, Netherlands

Source: Mycoses Published:2020

Abstract

Background: Emergence of coronavirus disease 2019 (COVID-19) is a major healthcare threat. Apparently, the novel coronavirus (SARS-CoV-2) is armed by special abilities to spread and dysregulate the immune mechanisms. The likelihood of oropharyngeal candidiasis (OPC) development in COVID-19 patients with a list of attributable risk factors for oral infections has not yet been investigated. Objectives: We here aim to investigate the prevalence, causative agents and antifungal susceptibility pattern of OPC in Iranian COVID-19 patients. Patients and Methods: A total of 53 hospitalised COVID-19 patients with OPC were studied. Relevant clinical data were mined. Strain identification was performed by 21-plex PCR and sequencing of the internal transcribed spacer region (ITS1-5.8S-ITS2). Antifungal susceptibility testing to fluconazole, itraconazole, voriconazole, amphotericin B, caspofungin, micafungin and anidulafungin was performed according to the CLSI broth dilution method. Results: In 53 COVID-19 patients with OPC, cardiovascular diseases (52.83%) and diabetes (37.7%) were the principal underlying conditions. The most common risk factor was lymphopaenia (71%). In total, 65 Candida isolates causing OPC were recovered. C albicans (70.7%) was the most common, followed by C glabrata (10.7%), C dubliniensis (9.2%), C parapsilosis sensu stricto (4.6%), C tropicalis (3%) and Pichia kudriavzevii (=C krusei, 1.5%). Majority of the Candida isolates were susceptible to all three classes of antifungal drugs. Conclusion: Our data clarified some concerns regarding the occurrence of OPC in Iranian COVID-19 patients. Further studies should be conducted to design an appropriate prophylaxis programme and improve management of OPC in critically ill COVID-19 patients. © 2020 Blackwell Verlag GmbH

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Nima Rezaei (27)

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Style	Citing Format
MLA	Salehi M, et al.. "Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern." Mycoses, vol. 63, no. 8, 2020, pp. 771-778.
APA	Salehi M, Ahmadikia K, Mahmoudi S, Kalantari S, Jamalimoghadamsiahkali S, Izadi A, Kord M, Dehghan Manshadi SA, Seifi A, Ghiasvand F, Khajavirad N, Ebrahimi S, Koohfar A, Boekhout T, Khodavaisy S (2020). Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern. Mycoses, 63(8), 771-778.
Chicago	Salehi M, Ahmadikia K, Mahmoudi S, Kalantari S, Jamalimoghadamsiahkali S, Izadi A, Kord M, et al.. "Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern." Mycoses 63, no. 8 (2020): 771-778.
Harvard	Salehi M et al. (2020) 'Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern', Mycoses, 63(8), pp. 771-778.
Vancouver	Salehi M, Ahmadikia K, Mahmoudi S, Kalantari S, Jamalimoghadamsiahkali S, Izadi A, et al.. Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern. Mycoses. 2020;63(8):771-778.
BibTex	@article{ author = {Salehi M and Ahmadikia K and Mahmoudi S and Kalantari S and Jamalimoghadamsiahkali S and Izadi A and Kord M and Dehghan Manshadi SA and Seifi A and Ghiasvand F and Khajavirad N and Ebrahimi S and Koohfar A and Boekhout T and Khodavaisy S}, title = {Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern}, journal = {Mycoses}, volume = {63}, number = {8}, pages = {771-778}, year = {2020} }
RIS	TY - JOUR AU - Salehi M AU - Ahmadikia K AU - Mahmoudi S AU - Kalantari S AU - Jamalimoghadamsiahkali S AU - Izadi A AU - Kord M AU - Dehghan Manshadi SA AU - Seifi A AU - Ghiasvand F AU - Khajavirad N AU - Ebrahimi S AU - Koohfar A AU - Boekhout T AU - Khodavaisy S TI - Oropharyngeal Candidiasis in Hospitalised Covid-19 Patients From Iran: Species Identification and Antifungal Susceptibility Pattern JO - Mycoses VL - 63 IS - 8 SP - 771 EP - 778 PY - 2020 ER -

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