Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents

Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents Publisher Pubmed

Mahdavi M¹ ; Dianat S² ; Khavari B³ ; Moghimi S⁴ ; Abdollahi M⁵ ; Safavi M⁶ ; Mouradzadegun A² ; Kabudanian Ardestani S³ ; Sabourian R⁷ ; Emami S⁸ ; Akbarzadeh T^{4, 7} ; Shafiee A⁴ ; Foroumadi A^{1, 4}

Show Affiliations

1. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Chemistry, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran
3. Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Biotechnology, Iranian Research Organization for Science and Technology, Tehran, Iran
7. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
8. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Source: Chemical Biology and Drug Design Published:2017

Abstract

Groebke–Blackburn–Bienayme reaction has been utilized for the synthesis of new imidazo[1,2-a]pyrimidine derivatives as novel anticancer agents. The cytotoxic activities of compounds were evaluated against human cancer cell lines including MCF-7, T-47D, and MDA-MB-231, compared with etoposide as the standard drug. Among the tested compounds, hydroxy- and/or methoxy-phenyl derivatives (6a–c and 6k) with IC50 values of 6.72–14.36 μm were more potent than etoposide against all cell lines. The acridine orange/ethidium bromide double staining and DNA fragmentation studies demonstrated that the cytotoxic effect of 3-hydroxy-4-methoxyphenyl derivative 6c is associated with apoptosis in cancer cells. © 2016 John Wiley & Sons A/S

Style	Citing Format
MLA	Mahdavi M, et al.. "Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents." Chemical Biology and Drug Design, vol. 89, no. 5, 2017, pp. 797-805.
APA	Mahdavi M, Dianat S, Khavari B, Moghimi S, Abdollahi M, Safavi M, Mouradzadegun A, Kabudanian Ardestani S, Sabourian R, Emami S, Akbarzadeh T, Shafiee A, Foroumadi A (2017). Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents. Chemical Biology and Drug Design, 89(5), 797-805.
Chicago	Mahdavi M, Dianat S, Khavari B, Moghimi S, Abdollahi M, Safavi M, Mouradzadegun A, et al.. "Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents." Chemical Biology and Drug Design 89, no. 5 (2017): 797-805.
Harvard	Mahdavi M et al. (2017) 'Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents', Chemical Biology and Drug Design, 89(5), pp. 797-805.
Vancouver	Mahdavi M, Dianat S, Khavari B, Moghimi S, Abdollahi M, Safavi M, et al.. Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents. Chemical Biology and Drug Design. 2017;89(5):797-805.
BibTex	@article{ author = {Mahdavi M and Dianat S and Khavari B and Moghimi S and Abdollahi M and Safavi M and Mouradzadegun A and Kabudanian Ardestani S and Sabourian R and Emami S and Akbarzadeh T and Shafiee A and Foroumadi A}, title = {Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents}, journal = {Chemical Biology and Drug Design}, volume = {89}, number = {5}, pages = {797-805}, year = {2017} }
RIS	TY - JOUR AU - Mahdavi M AU - Dianat S AU - Khavari B AU - Moghimi S AU - Abdollahi M AU - Safavi M AU - Mouradzadegun A AU - Kabudanian Ardestani S AU - Sabourian R AU - Emami S AU - Akbarzadeh T AU - Shafiee A AU - Foroumadi A TI - Synthesis and Biological Evaluation of Novel Imidazopyrimidin-3-Amines As Anticancer Agents JO - Chemical Biology and Drug Design VL - 89 IS - 5 SP - 797 EP - 805 PY - 2017 ER -

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Abstract