Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Raffinose-Carboxymethyl Cellulose Hydrogel, Silk Fibroin, and Agbtc Mof: A Nanobiocomposite With Biomedical Applications Publisher



Nia SM1 ; Naderi N1 ; Aliabadi HAM2 ; Kashtiaray A1 ; Mahdavi M3 ; Eivazzadehkeihan R4 ; Maleki A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Nanobiotechnology Department, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran

Source: Cellulose Published:2024


Abstract

Natural polymer-based hydrogels have importance in tissue engineering, drug delivery systems, and wound dressings due to their non-toxicity, renewability, biocompatibility, and biodegradability. Also, hydrogels can be modified to increase their antibacterial activity and mechanical properties. In this study, a novel nanobiocomposite was fabricated using raffinose (Raff)-carboxymethyl cellulose (CMC) hydrogel, silk fibroin (SF), and AgBTC metal organic framework (MOF). The nanobiocomposite was characterized using Fourier transform infrared (FT-IR), field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), thermogravimetric analysis (TGA), and X-ray diffraction (XRD) analyses. After 48 h of incubation, the (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) (MTT) assay of Raff-CMC hydrogel/SF/AgBTC nanobiocomposite on HEK293T cells (human embryonic healthy kidney cell lines) and MCF-7 cells (human breast cancer cell lines) showed that the percentage of cell viability of the two cell lines was 90.46% and 29.18%, respectively. The measured hemolytic activity of the nanobiocomposite on human red blood cells was 2.39%, indicating its safety for use in the human circulatory system, as it did not cause significant hemolysis in erythrocytes compared to the negative control. The potential of the Raff-CMC hydrogel/SF/AgBTC nanobiocomposite to inhibit bacterial growth was investigated, and results showed that E. coli and S. aureus growth was restricted by 60.38% and 57.09%, respectively. As a result, considering the biocompatibility of nanobiocomposite with healthy cells, its antibacterial and anticancer activity, as well as its hemocompatibility, it can be considered a potential candidate for biomedical applications such as wound healing, tissue engineering, and cancer therapy. © The Author(s), under exclusive licence to Springer Nature B.V. 2024.
Related Docs
View other Related Docs
1. A Natural Nanocomposite Based on Gelatin-Collagen Hydrogel and Silk Fibroin Embedded With Znfe Ldh for Biological Applications, Process Biochemistry (2024)
2. Agar-Tragacanth/Silk Fibroin Hydrogel Containing Zn-Based Mof As a Novel Nanobiocomposite With Biological Activity, Scientific Reports (2024)
3. A Novel Magnetic Nanocomposite Based on Alginate-Tannic Acid Hydrogel Embedded With Silk Fibroin With Biological Activity and Hyperthermia Application, International Journal of Biological Macromolecules (2023)
4. Recent Advances on Biomedical Applications of Gellan Gum: A Review, Carbohydrate Polymers (2024)
5. Fabrication of a Magnetic Nanocomposite Based on Natural Hydrogel: Pectin, Tragacanth Gum, Silk Fibroin, and Integrated Graphitic Carbon Nitride for Hyperthermia and Biological Features, Carbohydrate Polymer Technologies and Applications (2024)
6. Magnetized Chitosan Hydrogel and Silk Fibroin, Reinforced With Pva: A Novel Nanobiocomposite for Biomedical and Hyperthermia Applications, RSC Advances (2023)
7. Magnetic Chitosan-Silk Fibroin Hydrogel/Graphene Oxide Nanobiocomposite for Biological and Hyperthermia Applications, Carbohydrate Polymers (2023)
8. A Novel Ternary Magnetic Nanobiocomposite Based on Tragacanth-Silk Fibroin Hydrogel for Hyperthermia and Biological Properties, Scientific Reports (2024)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (24)
Zahra Hassannejad (1)
Other Related Docs
9. Magnetic Xanthan Gum-Silk Fibroin Hydrogel: A Nanocomposite for Biological and Hyperthermia Applications, International Journal of Biological Macromolecules (2023)
10. Biocompatibility and Antimicrobial Investigation of Agar-Tannic Acid Hydrogel Reinforced With Silk Fibroin and Zinc Manganese Oxide Magnetic Microparticles, Journal of Inorganic and Organometallic Polymers and Materials (2022)
11. Hyperthermia and Biological Investigation of a Novel Magnetic Nanobiocomposite Based on Acacia Gum-Silk Fibroin Hydrogel Embedded With Poly Vinyl Alcohol, Heliyon (2024)
12. Review: The Latest Advances in Biomedical Applications of Chitosan Hydrogel As a Powerful Natural Structure With Eye-Catching Biological Properties, Journal of Materials Science (2022)
13. Biological Investigation of a Novel Nanocomposite Based on Functionalized Graphene Oxide Nanosheets With Pectin, Silk Fibroin and Zinc Chromite Nanoparticles, Journal of Biotechnology (2022)
14. Investigation of Biological Activity and Hyperthermia Application of a Quaternary Magnetic Nanobiocomposite Based on Functionalized Carbon Nitride Nanosheets by Carboxymethyl Cellulose Hydrogel and Silk Fibroin, Cellulose (2023)
15. A Novel, Bioactive and Antibacterial Scaffold Based on Functionalized Graphene Oxide With Lignin, Silk Fibroin and Zno Nanoparticles, Scientific Reports (2022)
16. Recent Advances on Biomedical Applications of Pectin-Containing Biomaterials, International Journal of Biological Macromolecules (2022)
17. Production of a Magnetic Nanocomposite for Biological and Hyperthermia Applications Based on Chitosan-Silk Fibroin Hydrogel Incorporated With Carbon Nitride, International Journal of Biological Macromolecules (2024)
18. Magnetic Carboxymethyl Cellulose-Silk Fibroin Hydrogel: A Ternary Nanobiocomposite Exhibiting Excellent Biological Activity and in Vitro Hyperthermia of Cancer Therapy, Journal of Biotechnology (2023)
19. Hybrid Bionanocomposite Containing Magnesium Hydroxide Nanoparticles Embedded in a Carboxymethyl Cellulose Hydrogel Plus Silk Fibroin As a Scaffold for Wound Dressing Applications, ACS Applied Materials and Interfaces (2021)
20. Unveiling the Synergy: Biocompatible Alginate-Cellulose Hydrogel Loaded With Silk Fibroin and Zinc Ferrite Nanoparticles for Enhanced Cell Adhesion, and Anti-Biofilm Activity, International Journal of Biological Macromolecules (2024)
21. Recent Advances on Hyperthermia Therapy Applications of Carbon-Based Nanocomposites, Colloids and Surfaces B: Biointerfaces (2023)
22. Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications, Scientific Reports (2022)
23. Fabrication and Biological Investigation of a Novel Star Polymer Based on Magnetic Cyclic Aromatic Polyimide Chains, Scientific Reports (2023)
24. Injectable Hydrogel Based on Silk Fibroin/Carboxymethyl Cellulose/Agarose Containing Polydopamine Functionalized Graphene Oxide With Conductivity, Hemostasis, Antibacterial, and Anti-Oxidant Properties for Full-Thickness Burn Healing, International Journal of Biological Macromolecules (2023)
25. Metal-Organic Framework-Based Nanomaterials for Bone Tissue Engineering and Wound Healing, Materials Today Chemistry (2022)
26. Tetracycline Removal From Aqueous Solutions Using Zeolitic Imidazolate Frameworks With Different Morphologies: A Mathematical Modeling, Chemosphere (2019)
27. Synthesis and Characterization of Cellulose, Β-Cyclodextrin, Silk Fibroin-Based Hydrogel Containing Copper-Doped Cobalt Ferrite Nanospheres and Exploration of Its Biocompatibility, Journal of Nanostructure in Chemistry (2023)
28. Pectin-Cellulose Hydrogel, Silk Fibroin and Magnesium Hydroxide Nanoparticles Hybrid Nanocomposites for Biomedical Applications, International Journal of Biological Macromolecules (2021)
29. Evaluation of Physical/Mechanical Properties of an Experimental Dental Composite Modified With a Zirconium-Based Metal-Organic Framework (Mof) As an Innovative Dental Filler, Dental Materials (2023)
30. Synergistic Effects of Doxorubicin Loaded Silk Fibroin Nanoparticles and Cu-Tio2 Nanoparticles for Local Chemo-Sonodynamic Therapy Against Breast Cancer, International Journal of Biological Macromolecules (2025)
31. Biomedical Applications of Bombyx Mori Silk in Skin Regeneration and Cutaneous Wound Healing, Biomedical Materials (Bristol) (2025)