Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines

Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines Publisher Pubmed

Ahmadi R¹ ; Heidarian E² ; Fadaei R³ ; Moradi N¹ ; Malek M⁴ ; Fallah S¹

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1. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, Iran
2. Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
3. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

Source: Clinical Laboratory Published:2018

Abstract

Background: Atherosclerosis is a progressive inflammatory disease and is the main underlying mechanism of coronary artery disease (CAD). Immune system cells and cytokines play pivotal roles in the development of atherosclerosis. Several studies have shown the role of microRNA in the inflammatory processes of atherosclerosis, and miR-342-5p has been shown to be involved in macrophage activation during atherosclerosis and cytokine secretion. But until now, there has been no data regarding the association of miR-342-5p with CAD and inflammatory cytokines. Methods: This case control study was conducted on 82 CAD patients and 80 controls. Peripheral blood mononuclear cell (PBMC) miR-342-5p expression and gene expression of IL-6 and TNF-α were evaluated using real time- PCR. Also, the serum levels of IL-6 and TNF-α were measured using ELISA kits. Results: The results demonstrated a higher expression of miR-342-5p in CAD patients compared to controls (p < 0.001). Moreover, logistic regression revealed an increased risk of CAD according to the expression of miR- 342-5p after adjusting for CAD risk factors (OR [CI] = 6.1 [1.0 - 37.2], p = 0.048). Also, serum IL-6 and TNF-α showed higher levels in CAD patients (p = 0.003 and p = 0.004, respectively). Furthermore, there were positive correlations of miR-342-5p with gene expressions and serum levels of IL-6 and TNF-α. Conclusions: The present study demonstrated higher levels of miR-342-5p in CAD patients and showed positive correlation with inflammatory cytokines. This result is in accordance with a previous study, and suggested a regulatory role for miR-342-5p in atherosclerosis and cytokine secretion, although more studies are required in this direction. © 2018 Verlag Klinisches Labor GmbH. All rights reserved.

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Style	Citing Format
MLA	Ahmadi R, et al.. "Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines." Clinical Laboratory, vol. 64, no. 4, 2018, pp. 603-609.
APA	Ahmadi R, Heidarian E, Fadaei R, Moradi N, Malek M, Fallah S (2018). Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines. Clinical Laboratory, 64(4), 603-609.
Chicago	Ahmadi R, Heidarian E, Fadaei R, Moradi N, Malek M, Fallah S. "Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines." Clinical Laboratory 64, no. 4 (2018): 603-609.
Harvard	Ahmadi R et al. (2018) 'Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines', Clinical Laboratory, 64(4), pp. 603-609.
Vancouver	Ahmadi R, Heidarian E, Fadaei R, Moradi N, Malek M, Fallah S. Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines. Clinical Laboratory. 2018;64(4):603-609.
BibTex	@article{ author = {Ahmadi R and Heidarian E and Fadaei R and Moradi N and Malek M and Fallah S}, title = {Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines}, journal = {Clinical Laboratory}, volume = {64}, number = {4}, pages = {603-609}, year = {2018} }
RIS	TY - JOUR AU - Ahmadi R AU - Heidarian E AU - Fadaei R AU - Moradi N AU - Malek M AU - Fallah S TI - Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines JO - Clinical Laboratory VL - 64 IS - 4 SP - 603 EP - 609 PY - 2018 ER -

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